An Increase of Plasma Advanced Oxidation Protein Products Levels Is Associated with Cardiovascular Risk in Incident Peritoneal Dialysis Patients: A Pilot Study
Joint Authors
Lindholm, Bengt
Selgas, Rafael
del Peso, Gloria
Gonzalez, Elena
Bajo, Maria-Auxiliadora
Carrero, Juan J.
Grande, Cristina
Sánchez-Villanueva, Rafael
Díaz-Almirón, Mariana
Iglesias, Pedro
Díez, Juan J.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Advanced oxidation protein products (AOPPs) are considered as markers and even mediators of the proinflammatory effect of oxidative stress in uremia.
We hypothesized that an increase of oxidative stress associated with peritoneal dialysis (PD), estimated by the variation of plasma AOPPs over time, might be associated with cardiovascular (CV) risk and overall prognosis.
In 48 PD patients, blood samples were collected on two occasions: the first one in the first six months after starting PD therapy and the second one, one year after.
The plasma AOPPs level variation over the first year on PD was significantly associated with CV antecedents and also with CV prognosis.
In those patients in whom the AOPPs levels increased more than 50% above the baseline value, a significant association with past and future CV disease was confirmed.
These patients had 4.7 times greater risk of suffering later CV disease than those with a smaller increase, even after adjusting for previous CV history.
Our data suggest that the increase of AOPPs plasma level over the first year on PD is conditioned by CV antecedents but also independently predicts CV prognosis.
AOPPs plasma levels seem to represent the CV status of PD patients with sufficient sensitivity to identify those with a clearly sustained higher CV risk.
American Psychological Association (APA)
Gonzalez, Elena& Bajo, Maria-Auxiliadora& Carrero, Juan J.& Lindholm, Bengt& Grande, Cristina& Sánchez-Villanueva, Rafael…[et al.]. 2015. An Increase of Plasma Advanced Oxidation Protein Products Levels Is Associated with Cardiovascular Risk in Incident Peritoneal Dialysis Patients: A Pilot Study. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1075566
Modern Language Association (MLA)
Gonzalez, Elena…[et al.]. An Increase of Plasma Advanced Oxidation Protein Products Levels Is Associated with Cardiovascular Risk in Incident Peritoneal Dialysis Patients: A Pilot Study. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1075566
American Medical Association (AMA)
Gonzalez, Elena& Bajo, Maria-Auxiliadora& Carrero, Juan J.& Lindholm, Bengt& Grande, Cristina& Sánchez-Villanueva, Rafael…[et al.]. An Increase of Plasma Advanced Oxidation Protein Products Levels Is Associated with Cardiovascular Risk in Incident Peritoneal Dialysis Patients: A Pilot Study. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1075566
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075566