Iron-Induced Damage in Cardiomyopathy: Oxidative-Dependent and Independent Mechanisms
Joint Authors
Gammella, Elena
Recalcati, Stefania
Rybinska, Ilona
Buratti, Paolo
Cairo, Gaetano
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The high incidence of cardiomyopathy in patients with hemosiderosis, particularly in transfusional iron overload, strongly indicates that iron accumulation in the heart plays a major role in the process leading to heart failure.
In this context, iron-mediated generation of noxious reactive oxygen species is believed to be the most important pathogenetic mechanism determining cardiomyocyte damage, the initiating event of a pathologic progression involving apoptosis, fibrosis, and ultimately cardiac dysfunction.
However, recent findings suggest that additional mechanisms involving subcellular organelles and inflammatory mediators are important factors in the development of this disease.
Moreover, excess iron can amplify the cardiotoxic effect of other agents or events.
Finally, subcellular misdistribution of iron within cardiomyocytes may represent an additional pathway leading to cardiac injury.
Recent advances in imaging techniques and chelators development remarkably improved cardiac iron overload detection and treatment, respectively.
However, increased understanding of the pathogenic mechanisms of iron overload cardiomyopathy is needed to pave the way for the development of improved therapeutic strategies.
American Psychological Association (APA)
Gammella, Elena& Recalcati, Stefania& Rybinska, Ilona& Buratti, Paolo& Cairo, Gaetano. 2015. Iron-Induced Damage in Cardiomyopathy: Oxidative-Dependent and Independent Mechanisms. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075567
Modern Language Association (MLA)
Gammella, Elena…[et al.]. Iron-Induced Damage in Cardiomyopathy: Oxidative-Dependent and Independent Mechanisms. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075567
American Medical Association (AMA)
Gammella, Elena& Recalcati, Stefania& Rybinska, Ilona& Buratti, Paolo& Cairo, Gaetano. Iron-Induced Damage in Cardiomyopathy: Oxidative-Dependent and Independent Mechanisms. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075567