The Mitochondrial Translocator Protein and Arrhythmogenesis in Ischemic Heart Disease
Joint Authors
Motloch, Lukas J.
Hu, Jun
Akar, Fadi G.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mitochondrial dysfunction is a hallmark of multiple cardiovascular disorders, including ischemic heart disease.
Although mitochondria are well recognized for their role in energy production and cell death, mechanisms by which they control excitation-contraction coupling, excitability, and arrhythmias are less clear.
The translocator protein (TSPO) is an outer mitochondrial membrane protein that is expressed in multiple organ systems.
The abundant expression of TSPO in macrophages has been leveraged to image the immune response of the heart to inflammatory processes.
More recently, the recognition of TSPO as a regulator of energy-dissipating mitochondrial pathways has extended its utility from a diagnostic marker of inflammation to a therapeutic target influencing diverse pathophysiological processes.
Here, we provide an overview of the emerging role of TSPO in ischemic heart disease.
We highlight the importance of TSPO in the regenerative process of reactive oxygen species (ROS) induced ROS release through its effects on the inner membrane anion channel (IMAC) and the permeability transition pore (PTP).
We discuss evidence implicating TSPO in arrhythmogenesis in the settings of acute ischemia-reperfusion injury and myocardial infarction.
American Psychological Association (APA)
Motloch, Lukas J.& Hu, Jun& Akar, Fadi G.. 2015. The Mitochondrial Translocator Protein and Arrhythmogenesis in Ischemic Heart Disease. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075568
Modern Language Association (MLA)
Motloch, Lukas J.…[et al.]. The Mitochondrial Translocator Protein and Arrhythmogenesis in Ischemic Heart Disease. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075568
American Medical Association (AMA)
Motloch, Lukas J.& Hu, Jun& Akar, Fadi G.. The Mitochondrial Translocator Protein and Arrhythmogenesis in Ischemic Heart Disease. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075568