Psychiatric Disorders and Polyphenols: Can They Be Helpful in Therapy?
Joint Authors
Durackova, Zdenka
Trebatická, Jana
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-09
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The prevalence of psychiatric disorders permanently increases.
Polyphenolic compounds can be involved in modulation of mental health including brain plasticity, behaviour, mood, depression, and cognition.
In addition to their antioxidant ability other biomodulating properties have been observed.
In the pathogenesis of depression disturbance in neurotransmitters, increased inflammatory processes, defects in neurogenesis and synaptic plasticity, mitochondrial dysfunction, and redox imbalance are observed.
Ginkgo biloba, green tea, and Quercus robur extracts and curcumin can affect neuronal system in depressive patients.
ADHD patients treated with antipsychotic drugs, especially stimulants, report significant adverse effects; therefore, an alternative treatment is searched for.
An extract from Ginkgo biloba and from Pinus pinaster bark, Pycnogenol, could become promising complementary supplements in ADHD treatment.
Schizophrenia is a devastating mental disorder, with oxidative stress involved in its pathophysiology.
The direct interference of polyphenols with schizophrenia pathophysiology has not been reported yet.
However, increased oxidative stress caused by haloperidol was inhibited ex vivo by different polyphenols.
Curcumin, extract from green tea and from Ginkgo biloba, may have benefits on serious side effects associated with administration of neuroleptics to patients suffering from schizophrenia.
Polyphenols in the diet have the potential to become medicaments in the field of mental health after a thorough study of their mechanism of action.
American Psychological Association (APA)
Trebatická, Jana& Durackova, Zdenka. 2015. Psychiatric Disorders and Polyphenols: Can They Be Helpful in Therapy?. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1075572
Modern Language Association (MLA)
Trebatická, Jana& Durackova, Zdenka. Psychiatric Disorders and Polyphenols: Can They Be Helpful in Therapy?. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1075572
American Medical Association (AMA)
Trebatická, Jana& Durackova, Zdenka. Psychiatric Disorders and Polyphenols: Can They Be Helpful in Therapy?. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1075572
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075572