Inhibition of Adenylyl Cyclase Type 5 Increases Longevity and Healthful Aging through Oxidative Stress Protection
Joint Authors
Vatner, Stephen F.
Pachon, Ronald E.
Vatner, Dorothy E.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Mice with disruption of adenylyl cyclase type 5 (AC5 knockout, KO) live a third longer than littermates.
The mechanism, in part, involves the MEK/ERK pathway, which in turn is related to protection against oxidative stress.
The AC5 KO model also protects against diabetes, obesity, and the cardiomyopathy induced by aging, diabetes, and cardiac stress and also demonstrates improved exercise capacity.
All of these salutary features are also mediated, in part, by oxidative stress protection.
For example, chronic beta adrenergic receptor stimulation induced cardiomyopathy was rescued by AC5 KO.
Conversely, in AC5 transgenic (Tg) mice, where AC5 is overexpressed in the heart, the cardiomyopathy was exacerbated and was rescued by enhancing oxidative stress resistance.
Thus, the AC5 KO model, which resists oxidative stress, is uniquely designed for clinical translation, since it not only increases longevity and exercise, but also protects against diabetes, obesity, and cardiomyopathy.
Importantly, inhibition of AC5’s action to prolong longevity and enhance healthful aging, as well as its mechanism through resistance to oxidative stress, is unique among all of the nine AC isoforms.
American Psychological Association (APA)
Vatner, Stephen F.& Pachon, Ronald E.& Vatner, Dorothy E.. 2015. Inhibition of Adenylyl Cyclase Type 5 Increases Longevity and Healthful Aging through Oxidative Stress Protection. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075573
Modern Language Association (MLA)
Vatner, Stephen F.…[et al.]. Inhibition of Adenylyl Cyclase Type 5 Increases Longevity and Healthful Aging through Oxidative Stress Protection. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1075573
American Medical Association (AMA)
Vatner, Stephen F.& Pachon, Ronald E.& Vatner, Dorothy E.. Inhibition of Adenylyl Cyclase Type 5 Increases Longevity and Healthful Aging through Oxidative Stress Protection. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075573