Epicatechin Reduces Striatal MPP+-Induced Damage in Rats through Slight Increases in SOD-Cu,Zn Activity
Joint Authors
Montes, Sergio
Ríos, Camilo
Rubio-Osornio, M.
Gorostieta-Salas, E.
Pérez-Severiano, F.
Rubio, C.
Gómez, C.
Guevara, J.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Parkinson’s disease is a neurodegenerative disorder characterized by movement alterations caused by reduced dopaminergic neurotransmission in the nigrostriatal pathway, presumably by oxidative stress (OS).
MPP+ intrastriatal injection leads to the overproduction of free radicals (FR).
The increasing formation of FR produces OS, a decline in dopamine (DA) content, and behavioral disorders.
Epicatechin (EC) has shown the ability to be FR scavenger, an antioxidant enzyme inductor, a redox state modulator, and transition metal chelator.
Acute administration of 100 mg/kg of EC significantly prevented (P<0.05) the circling MPP+-induced behavior (10 μg/8 μL).
Likewise, EC significantly (P<0.05) reduced the formation of fluorescent lipid products caused by MPP+.
MPP+ injection produced (P<0.05) increased enzymatic activity of the constitutive nitric oxide synthase (cNOS).
This effect was blocked with acute EC pretreatment.
Cu/Zn-dependent superoxide dismutase (Cu/Zn-SOD) activity was significantly (P<0.05) reduced as a consequence of MPP+ damage.
EC produced a slight increase (≈20%) in Cu/Zn-SOD activity in the control group.
Such effects persisted in animals injured with MPP+.
The results show that EC is effective against MPP+-induced biochemical and behavioral damage, which is possible by an increase in Cu/Zn-SOD activity.
American Psychological Association (APA)
Rubio-Osornio, M.& Gorostieta-Salas, E.& Montes, Sergio& Pérez-Severiano, F.& Rubio, C.& Gómez, C.…[et al.]. 2015. Epicatechin Reduces Striatal MPP+-Induced Damage in Rats through Slight Increases in SOD-Cu,Zn Activity. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1075577
Modern Language Association (MLA)
Rubio-Osornio, M.…[et al.]. Epicatechin Reduces Striatal MPP+-Induced Damage in Rats through Slight Increases in SOD-Cu,Zn Activity. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1075577
American Medical Association (AMA)
Rubio-Osornio, M.& Gorostieta-Salas, E.& Montes, Sergio& Pérez-Severiano, F.& Rubio, C.& Gómez, C.…[et al.]. Epicatechin Reduces Striatal MPP+-Induced Damage in Rats through Slight Increases in SOD-Cu,Zn Activity. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1075577
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075577