Increased Oxidative Stress as a Selective Anticancer Therapy
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Reactive oxygen species (ROS) are closely related to tumorgenesis.
Under hypoxic environment, increased levels of ROS induce the expression of hypoxia inducible factors (HIFs) in cancer stem cells (CSCs), resulting in the promotion of the upregulation of CSC markers, and the reduction of intracellular ROS level, thus facilitating CSCs survival and proliferation.
Although the ROS level is regulated by powerful antioxidant defense mechanisms in cancer cells, it is observed to remain higher than that in normal cells.
Cancer cells may be more sensitive than normal cells to the accumulation of ROS; consequently, it is supposed that increased oxidative stress by exogenous ROS generation therapy has an effect on selectively killing cancer cells without affecting normal cells.
This paper reviews the mechanisms of redox regulation in CSCs and the pivotal role of ROS in anticancer treatment.
American Psychological Association (APA)
Liu, Jiahui& Wang, Zhichong. 2015. Increased Oxidative Stress as a Selective Anticancer Therapy. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075580
Modern Language Association (MLA)
Liu, Jiahui& Wang, Zhichong. Increased Oxidative Stress as a Selective Anticancer Therapy. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075580
American Medical Association (AMA)
Liu, Jiahui& Wang, Zhichong. Increased Oxidative Stress as a Selective Anticancer Therapy. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075580