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Protocatechuic Acid Prevents oxLDL-Induced Apoptosis by Activating JNKNrf2 Survival Signals in Macrophages
Joint Authors
Masella, Roberta
Filesi, Carmelina
Varì, Rosaria
Scazzocchio, Beatrice
Santangelo, Carmela
D’Archivio, Massimo
Giovannini, Claudio
Galvano, Fabio
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Protocatechuic acid (PCA), one of the main metabolites of complex polyphenols, exerts numerous biological activities including antiapoptotic, anti-inflammatory, and antiatherosclerotic effects.
Oxidised LDL have atherogenic properties by damaging arterial wall cells and inducing p53-dependent apoptosis in macrophages.
This study was aimed at defining the molecular mechanism responsible for the protective effects of PCA against oxidative and proapoptotic damage exerted by oxLDL in J774 A.1 macrophages.
We found that the presence of PCA in cells treated with oxLDL completely inhibited the p53-dependent apoptosis induced by oxLDL.
PCA decreased oxLDL-induced ROS overproduction and in particular prevented the early increase of ROS.
This decrease seemed to be the main signal responsible for maintaining the intracellular redox homeostasis hindering the activation of p53 induced by ROS, p38MAPK, and PKCδ.
Consequently the overexpression of the proapoptotic p53-target genes such as p66Shc protein did not occur.
Finally, we demonstrated that PCA induced the activation of JNK, which, in turn, determined the increase of nuclear Nrf2, leading to inhibition of the early ROS overproduction.
We concluded that the antiapoptotic mechanism of PCA was most likely related to the activation of the JNK-mediated survival signals that strengthen the cellular antioxidant defences rather than to the PCA antioxidant power.
American Psychological Association (APA)
Varì, Rosaria& Scazzocchio, Beatrice& Santangelo, Carmela& Filesi, Carmelina& Galvano, Fabio& D’Archivio, Massimo…[et al.]. 2015. Protocatechuic Acid Prevents oxLDL-Induced Apoptosis by Activating JNKNrf2 Survival Signals in Macrophages. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075597
Modern Language Association (MLA)
Varì, Rosaria…[et al.]. Protocatechuic Acid Prevents oxLDL-Induced Apoptosis by Activating JNKNrf2 Survival Signals in Macrophages. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075597
American Medical Association (AMA)
Varì, Rosaria& Scazzocchio, Beatrice& Santangelo, Carmela& Filesi, Carmelina& Galvano, Fabio& D’Archivio, Massimo…[et al.]. Protocatechuic Acid Prevents oxLDL-Induced Apoptosis by Activating JNKNrf2 Survival Signals in Macrophages. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075597