The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s Disease
Joint Authors
Xue, M.
Liu, Zhenzhen
Li, Tao
Li, Ping
Wei, Nannan
Zhao, Zhiquan
Liang, Huimin
Ji, Xinying
Chen, Wenwu
Wei, Jianshe
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is the most common form of dementia.
The pathological hallmarks of AD are amyloid plaques [aggregates of amyloid-beta (Aβ)] and neurofibrillary tangles (aggregates of tau).
Growing evidence suggests that tau accumulation is pathologically more relevant to the development of neurodegeneration and cognitive decline in AD patients than Aβ plaques.
Oxidative stress is a prominent early event in the pathogenesis of AD and is therefore believed to contribute to tau hyperphosphorylation.
Several studies have shown that the autophagic pathway in neurons is important under physiological and pathological conditions.
Therefore, this pathway plays a crucial role for the degradation of endogenous soluble tau.
However, the relationship between oxidative stress, tau protein hyperphosphorylation, autophagy dysregulation, and neuronal cell death in AD remains unclear.
Here, we review the latest progress in AD, with a special emphasis on oxidative stress, tau hyperphosphorylation, and autophagy.
We also discuss the relationship of these three factors in AD.
American Psychological Association (APA)
Liu, Zhenzhen& Li, Tao& Li, Ping& Wei, Nannan& Zhao, Zhiquan& Liang, Huimin…[et al.]. 2015. The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075598
Modern Language Association (MLA)
Liu, Zhenzhen…[et al.]. The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075598
American Medical Association (AMA)
Liu, Zhenzhen& Li, Tao& Li, Ping& Wei, Nannan& Zhao, Zhiquan& Liang, Huimin…[et al.]. The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075598
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075598