Role of Oxidative RNA Damage in Chronic-Degenerative Diseases
Author
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Normal cellular metabolism and exposure to ionizing and ultraviolet radiations and exogenous agents produce reactive oxygen species (ROS).
Due to their reactivity, they can interact with many critical biomolecules and induce cell damage.
The reaction of ROS with free nucleobases, nucleosides, nucleotides, or oligonucleotides can generate numerous distinct modifications in nucleic acids.
Oxidative damage to DNA has been widely investigated and is strongly implicated in the development of many chronic-degenerative diseases.
In contrast, RNA damage is a poorly examined field in biomedical research.
In this review, I discuss the importance of RNA as a target of oxidative damage and the role of oxidative damage to RNA in the pathogenesis of some chronic-degenerative diseases, such as neurological disorders, atherosclerosis, and cancer.
Furthermore, I review recent evidence suggesting that RNA may be the target for toxic agents and indicating RNA degradation as a powerful tool to treat any pathology in which there is an aberrant expression of mRNA and/or its gene products.
American Psychological Association (APA)
Fimognari, Carmela. 2015. Role of Oxidative RNA Damage in Chronic-Degenerative Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075600
Modern Language Association (MLA)
Fimognari, Carmela. Role of Oxidative RNA Damage in Chronic-Degenerative Diseases. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075600
American Medical Association (AMA)
Fimognari, Carmela. Role of Oxidative RNA Damage in Chronic-Degenerative Diseases. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075600