Mechanical Ventilation Induces an Inflammatory Response in Preinjured Lungs in Late Phase of Sepsis
Joint Authors
Xuan, Wei
Zhou, Quanjun
Yao, Shanglong
Deng, Qingzhu
Wang, Tingting
Wu, Qingping
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mechanical ventilation (MV) may amplify the lung-specific inflammatory response in preinjured lungs by elevating cytokine release and augmenting damage to the alveolar integrity.
In this study, we test the hypothesis that MV exerts different negative impacts on inflammatory response at different time points of postlung injury.
Basic lung injury was induced by cecal ligation and puncture (CLP) surgery in rats.
Physiological indexes including blood gases were monitored during MV and samples were assessed following each experiment.
Low VT (tidal volume) MV caused a slight increase in cytokine release and tissue damage at day 1 and day 4 after sepsis induced lung injury, while cytokine release from the lungs in the two moderately ventilated VT groups was amplified.
Interestingly, in the two groups where rats received low VT MV, we found that infiltration of inflammatory cells was only profound at day 4 after CLP.
Marked elevation of protein leakage indicated a compromise in alveolar integrity in rats that received moderate VT MV at day 4 following CLP, correlating with architectural damage to the alveoli.
Our study indicates that preinjured lungs are more sensitive to mechanical MV at later phases of sepsis, and this situation may be a result of differing immune status.
American Psychological Association (APA)
Xuan, Wei& Zhou, Quanjun& Yao, Shanglong& Deng, Qingzhu& Wang, Tingting& Wu, Qingping. 2015. Mechanical Ventilation Induces an Inflammatory Response in Preinjured Lungs in Late Phase of Sepsis. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075605
Modern Language Association (MLA)
Xuan, Wei…[et al.]. Mechanical Ventilation Induces an Inflammatory Response in Preinjured Lungs in Late Phase of Sepsis. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075605
American Medical Association (AMA)
Xuan, Wei& Zhou, Quanjun& Yao, Shanglong& Deng, Qingzhu& Wang, Tingting& Wu, Qingping. Mechanical Ventilation Induces an Inflammatory Response in Preinjured Lungs in Late Phase of Sepsis. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075605