Traumatic Brain Injury and NADPH Oxidase: A Deep Relationship
Joint Authors
Prata, Cecilia
Vieceli Dalla Sega, Francesco
Piperno, Roberto
Angeloni, Cristina
Hrelia, Silvana
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Traumatic brain injury (TBI) represents one of the major causes of mortality and disability in the world.
TBI is characterized by primary damage resulting from the mechanical forces applied to the head as a direct result of the trauma and by the subsequent secondary injury due to a complex cascade of biochemical events that eventually lead to neuronal cell death.
Oxidative stress plays a pivotal role in the genesis of the delayed harmful effects contributing to permanent damage.
NADPH oxidases (Nox), ubiquitary membrane multisubunit enzymes whose unique function is the production of reactive oxygen species (ROS), have been shown to be a major source of ROS in the brain and to be involved in several neurological diseases.
Emerging evidence demonstrates that Nox is upregulated after TBI, suggesting Nox critical role in the onset and development of this pathology.
In this review, we summarize the current evidence about the role of Nox enzymes in the pathophysiology of TBI.
American Psychological Association (APA)
Angeloni, Cristina& Prata, Cecilia& Vieceli Dalla Sega, Francesco& Piperno, Roberto& Hrelia, Silvana. 2015. Traumatic Brain Injury and NADPH Oxidase: A Deep Relationship. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075606
Modern Language Association (MLA)
Angeloni, Cristina…[et al.]. Traumatic Brain Injury and NADPH Oxidase: A Deep Relationship. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075606
American Medical Association (AMA)
Angeloni, Cristina& Prata, Cecilia& Vieceli Dalla Sega, Francesco& Piperno, Roberto& Hrelia, Silvana. Traumatic Brain Injury and NADPH Oxidase: A Deep Relationship. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075606