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Preventive Treatment with Ketamine Attenuates the Ischaemia-Reperfusion Response in a Chronic Postischaemia Pain Model
Joint Authors
Irwin, Michael G.
Tai, Lydia W.
Qiu, Qiu
Cheung, C. W.
Liman, Suryamin
Wong, Kar Lok
Ng, Kwok Fu
Choi, Siu Wai
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ischemia and inflammation may be pathophysiological mechanisms of complex regional pain syndrome (CRPS).
Ketamine has proposed anti-inflammatory effects and has been used for treating CRPS.
This study aimed to evaluate anti-inflammatory and analgesic effects of ketamine after ischaemia-reperfusion injury in a chronic postischaemia pain (CPIP) model of CRPS-I.
Using this model, ischemia was induced in the hindlimbs of male Sprague-Dawley rats.
Ketamine, methylprednisolone, or saline was administered immediately after reperfusion.
Physical effects, (oedema, temperature, and mechanical and cold allodynia) in the bilateral hindpaws, were assessed from 48 hours after reperfusion.
Fewer (56%) rats in the ketamine group developed CPIP at the 48th hour after reperfusion (nonsignificant).
Ketamine treated rats showed a significantly lower temperature in the ischaemic hindpaw compared to saline (P<0.01) and methylprednisolone (P<0.05) groups.
Mechanical and cold allodynia were significantly lower in the ischaemic side in the ketamine group (P<0.05).
Proinflammatory cytokines TNF-α and IL-2 were significantly lower at the 48th hour after reperfusion in ketamine and methylprednisolone groups, compared to saline (all P<0.05).
In conclusion, immediate administration of ketamine after an ischaemia-reperfusion injury can alleviate pain and inflammation in the CPIP model and has potential to treat postischaemic pain.
American Psychological Association (APA)
Liman, Suryamin& Cheung, C. W.& Wong, Kar Lok& Tai, Lydia W.& Qiu, Qiu& Ng, Kwok Fu…[et al.]. 2015. Preventive Treatment with Ketamine Attenuates the Ischaemia-Reperfusion Response in a Chronic Postischaemia Pain Model. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075608
Modern Language Association (MLA)
Liman, Suryamin…[et al.]. Preventive Treatment with Ketamine Attenuates the Ischaemia-Reperfusion Response in a Chronic Postischaemia Pain Model. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1075608
American Medical Association (AMA)
Liman, Suryamin& Cheung, C. W.& Wong, Kar Lok& Tai, Lydia W.& Qiu, Qiu& Ng, Kwok Fu…[et al.]. Preventive Treatment with Ketamine Attenuates the Ischaemia-Reperfusion Response in a Chronic Postischaemia Pain Model. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075608
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075608