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Chronic Stress Facilitates the Development of Deep Venous Thrombosis
Joint Authors
Dong, Tao
Cheng, Yu-Wen
Yang, Fei
Sun, Pei-Wen
Zhu, Chen-Jie
Zhu, Li
Zhang, Guo-Xing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The increasing pressure of modern social life intensifies the impact of stress on the development of cardiovascular diseases, which include deep venous thrombosis (DVT).
Renal sympathetic denervation has been applied as one of the clinical approaches for the treatment of drug-resistant hypertension.
In addition, the close relationship between oxidative stress and cardiovascular diseases has been well documented.
The present study is designed to explore the mechanism by which the renal sympathetic nerve system and the oxidative stress affect the blood coagulation system in the development of DVT.
Chronic foot shock model in rats was applied to mimic a state of physiological stress similar to humans.
Our results showed that chronic foot shock procedure could promote DVT which may be through the activation of platelets aggregation.
The aggravation of DVT and activation of platelets were alleviated by renal sympathetic denervation or antioxidant (Tempol) treatment.
Concurrently, the denervation treatment could also reduce the levels of circulating oxidation factors in rats.
These results demonstrate that both the renal sympathetic nerve system and the oxidative stress contribute to the development of DVT in response to chronic stress, which may provide novel strategy for treatment of clinic DVT patients.
American Psychological Association (APA)
Dong, Tao& Cheng, Yu-Wen& Yang, Fei& Sun, Pei-Wen& Zhu, Chen-Jie& Zhu, Li…[et al.]. 2015. Chronic Stress Facilitates the Development of Deep Venous Thrombosis. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075611
Modern Language Association (MLA)
Dong, Tao…[et al.]. Chronic Stress Facilitates the Development of Deep Venous Thrombosis. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075611
American Medical Association (AMA)
Dong, Tao& Cheng, Yu-Wen& Yang, Fei& Sun, Pei-Wen& Zhu, Chen-Jie& Zhu, Li…[et al.]. Chronic Stress Facilitates the Development of Deep Venous Thrombosis. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075611