Resveratrol Derivative-Rich Melinjo Seed Extract Attenuates Skin Atrophy in Sod1-Deficient Mice
Joint Authors
Shimizu, Takahiko
Watanabe, Kenji
Shibuya, Shuichi
Ozawa, Yusuke
Izuo, Naotaka
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The oxidative damages induced by a redox imbalance cause age-related changes in cells and tissues.
Superoxide dismutase (SOD) enzymes play a pivotal role in the antioxidant system and they also catalyze superoxide radicals.
Since the loss of cytoplasmic SOD (SOD1) resulted in aging-like phenotypes in several types of murine tissue, SOD1 is essential for the maintenance of tissue homeostasis.
Melinjo (Gnetum gnemon Linn) seed extract (MSE) contains trans-resveratrol (RSV) and resveratrol derivatives, including gnetin C, gnemonoside A, and gnemonoside D.
MSE intake also exerts no adverse events in human study.
In the present studies, we investigated protective effects of MSE on age-related skin pathologies in mice.
Orally MSE and RSV treatment reversed the skin thinning associated with increased oxidative damage in the Sod1−/− mice.
Furthermore, MSE and RSV normalized gene expression of Col1a1 and p53 and upregulated gene expression of Sirt1 in skin tissues.
In vitro experiments revealed that RSV significantly promoted the viability of Sod1−/− fibroblasts.
These finding demonstrated that RSV in MSE stably suppressed an intrinsic superoxide generation in vivo and in vitro leading to protecting skin damages.
RSV derivative-rich MSE may be a powerful food of treatment for age-related skin diseases caused by oxidative damages.
American Psychological Association (APA)
Watanabe, Kenji& Shibuya, Shuichi& Ozawa, Yusuke& Izuo, Naotaka& Shimizu, Takahiko. 2015. Resveratrol Derivative-Rich Melinjo Seed Extract Attenuates Skin Atrophy in Sod1-Deficient Mice. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075612
Modern Language Association (MLA)
Watanabe, Kenji…[et al.]. Resveratrol Derivative-Rich Melinjo Seed Extract Attenuates Skin Atrophy in Sod1-Deficient Mice. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075612
American Medical Association (AMA)
Watanabe, Kenji& Shibuya, Shuichi& Ozawa, Yusuke& Izuo, Naotaka& Shimizu, Takahiko. Resveratrol Derivative-Rich Melinjo Seed Extract Attenuates Skin Atrophy in Sod1-Deficient Mice. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075612
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075612