Oxidative Stress: Dual Pathway Induction in Cardiorenal Syndrome Type 1 Pathogenesis
Joint Authors
Clementi, Anna
Ronco, Claudio
Brocca, Alessandra
Virzì, Grazia Maria
Pastori, Silvia
de Cal, Massimo
Vescovo, Giorgio
Day, Sonya
Bolin, Chiara
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cardiorenal Syndrome Type 1 (Type 1) is a specific condition which is characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI).
Even though its pathophysiology is complex and not still completely understood, oxidative stress seems to play a pivotal role.
In this study, we examined the putative role of oxidative stress in the pathogenesis of CRS Type 1.
Twenty-three patients with acute heart failure (AHF) were included in the study.
Subsequently, 11 patients who developed AKI due to AHF were classified as CRS Type 1.
Quantitative determinations for IL-6, myeloperoxidase (MPO), nitric oxide (NO), copper/zinc superoxide dismutase (Cu/ZnSOD), and endogenous peroxidase activity (EPA) were performed.
CRS Type 1 patients displayed significant augmentation in circulating ROS and RNS, as well as expression of IL-6.
Quantitative analysis of all oxidative stress markers showed significantly lower oxidative stress levels in controls and AHF compared to CRS Type 1 patients ( P < 0.05 ).
This pilot study demonstrates the significantly heightened presence of dual oxidative stress pathway induction in CRS Type 1 compared to AHF patients.
Our findings indicate that oxidative stress is a potential therapeutic target, as it promotes inflammation by ROS/RNS-linked pathogenesis.
American Psychological Association (APA)
Virzì, Grazia Maria& Clementi, Anna& de Cal, Massimo& Brocca, Alessandra& Day, Sonya& Pastori, Silvia…[et al.]. 2015. Oxidative Stress: Dual Pathway Induction in Cardiorenal Syndrome Type 1 Pathogenesis. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075615
Modern Language Association (MLA)
Virzì, Grazia Maria…[et al.]. Oxidative Stress: Dual Pathway Induction in Cardiorenal Syndrome Type 1 Pathogenesis. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1075615
American Medical Association (AMA)
Virzì, Grazia Maria& Clementi, Anna& de Cal, Massimo& Brocca, Alessandra& Day, Sonya& Pastori, Silvia…[et al.]. Oxidative Stress: Dual Pathway Induction in Cardiorenal Syndrome Type 1 Pathogenesis. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075615
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075615