Impact of Atmospheric Microparticles on the Development of Oxidative Stress in Healthy CityIndustrial Seaport Residents
Joint Authors
Golokhvast, Kirill S.
Chaika, Vladimir V.
Vitkina, Tatyana
Gvozdenko, Tatyana
Kolosov, Victor
Yankova, Vera
Kondratieva, Elena
Gorkavaya, Anna
Nazarenko, Anna
Romanova, Tatyana
Karabtsov, Alexander
Perelman, Juliy
Kiku, Pavel
Tsatsakis, Aristidis
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Atmospheric microsized particles producing reactive oxygen species can pose a serious health risk for city residents.
We studied the responses of organisms to microparticles in 255 healthy volunteers living in areas with different levels of microparticle air pollution.
We analyzed the distribution of microparticles in snow samples by size and content.
ELISA and flow cytometry methods were employed to determine the parameters of the thiol-disulfide metabolism, peroxidation and antioxidant, genotoxicity, and energy state of the leukocytes.
We found that, in the park areas, microparticles with a size of 800 μm or more were predominant (96%), while in the industrial areas, they tended to be less than 50 μm (93%), including size 200–300 nm (7%).
In the industrial areas, we determined the oxidative modification of proteins (21% compared to the park areas, p ≤ 0.05 ) and DNA (12%, p ≤ 0.05 ), as well as changes in leukocytes’ energy potential (53%, p ≤ 0.05 ).
An increase in total antioxidant activity (82%, p ≤ 0.01 ) and thiol-disulfide system response (thioredoxin increasing by 33%, p ≤ 0.01 ; glutathione, 30%, p ≤ 0.01 with stable reductases levels) maintains a balance of peroxidation-antioxidant processes, protecting cellular and subcellular structures from significant oxidative damage.
American Psychological Association (APA)
Golokhvast, Kirill S.& Vitkina, Tatyana& Gvozdenko, Tatyana& Kolosov, Victor& Yankova, Vera& Kondratieva, Elena…[et al.]. 2015. Impact of Atmospheric Microparticles on the Development of Oxidative Stress in Healthy CityIndustrial Seaport Residents. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075643
Modern Language Association (MLA)
Golokhvast, Kirill S.…[et al.]. Impact of Atmospheric Microparticles on the Development of Oxidative Stress in Healthy CityIndustrial Seaport Residents. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075643
American Medical Association (AMA)
Golokhvast, Kirill S.& Vitkina, Tatyana& Gvozdenko, Tatyana& Kolosov, Victor& Yankova, Vera& Kondratieva, Elena…[et al.]. Impact of Atmospheric Microparticles on the Development of Oxidative Stress in Healthy CityIndustrial Seaport Residents. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075643
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075643