Isoflavones Reduce Copper with Minimal Impact on Iron In Vitro
Joint Authors
Karlíčková, Jana
Macáková, Kateřina
Říha, Michal
Pinheiro, Liliane Maria Teixeira
Filipský, Tomáš
Horňasová, Veronika
Hrdina, Radomír
Mladěnka, Přemysl
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Isoflavones are commonly consumed in many Asian countries and have potentially positive effects on human being.
Only a few and rather controversial data on their interactions with copper and iron are available to date.
13 structurally related isoflavones were tested in the competitive manner for their Cu/Fe-chelating/reducing properties.
Notwithstanding the 5-hydroxy-4-keto chelation site was associated with ferric, ferrous, and cupric chelation, the chelation potential of isoflavones was low and no cuprous chelation was observed.
None of isoflavones was able to substantially reduce ferric ions, but the vast majority reduced cupric ions.
The most important feature for cupric reduction was the presence of an unsubstituted 4′-hydroxyl; contrarily the presence of a free 5-hydroxyl decreased or abolished the reduction due to chelation of cupric ions.
The results from this study may enable additional experiments which might clarify the effects of isoflavones on human being and/or mechanisms of copper absorption.
American Psychological Association (APA)
Karlíčková, Jana& Macáková, Kateřina& Říha, Michal& Pinheiro, Liliane Maria Teixeira& Hrdina, Radomír& Mladěnka, Přemysl…[et al.]. 2015. Isoflavones Reduce Copper with Minimal Impact on Iron In Vitro. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075654
Modern Language Association (MLA)
Hrdina, Radomír…[et al.]. Isoflavones Reduce Copper with Minimal Impact on Iron In Vitro. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075654
American Medical Association (AMA)
Karlíčková, Jana& Macáková, Kateřina& Říha, Michal& Pinheiro, Liliane Maria Teixeira& Hrdina, Radomír& Mladěnka, Přemysl…[et al.]. Isoflavones Reduce Copper with Minimal Impact on Iron In Vitro. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075654
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075654