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Oxidative Stress Responses and NRF2 in Human Leukaemia
Joint Authors
Abdul-Aziz, Amina
MacEwan, David J.
Bowles, Kristian M.
Rushworth, Stuart A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Oxidative stress as a result of elevated levels of reactive oxygen species (ROS) has been observed in almost all cancers, including leukaemia, where they contribute to disease development and progression.
However, cancer cells also express increased levels of antioxidant proteins which detoxify ROS.
This includes glutathione, the major antioxidant in human cells, which has recently been identified to have dysregulated metabolism in human leukaemia.
This suggests that critical balance of intracellular ROS levels is required for cancer cell function, growth, and survival.
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) transcription factor plays a dual role in cancer.
Primarily, NRF2 is a transcription factor functioning to protect nonmalignant cells from malignant transformation and oxidative stress through transcriptional activation of detoxifying and antioxidant enzymes.
However, once malignant transformation has occurred within a cell, NRF2 functions to protect the tumour from oxidative stress and chemotherapy-induced cytotoxicity.
Moreover, inhibition of the NRF2 oxidative stress pathway in leukaemia cells renders them more sensitive to cytotoxic chemotherapy.
Our improved understanding of NRF2 biology in human leukaemia may permit mechanisms by which we could potentially improve future cancer therapies.
This review highlights the mechanisms by which leukaemic cells exploit the NRF2/ROS response to promote their growth and survival.
American Psychological Association (APA)
Abdul-Aziz, Amina& MacEwan, David J.& Bowles, Kristian M.& Rushworth, Stuart A.. 2015. Oxidative Stress Responses and NRF2 in Human Leukaemia. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075658
Modern Language Association (MLA)
Abdul-Aziz, Amina…[et al.]. Oxidative Stress Responses and NRF2 in Human Leukaemia. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1075658
American Medical Association (AMA)
Abdul-Aziz, Amina& MacEwan, David J.& Bowles, Kristian M.& Rushworth, Stuart A.. Oxidative Stress Responses and NRF2 in Human Leukaemia. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075658
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075658