Hydrogen Sulfide: A Therapeutic Candidate for Fibrotic Disease?
Joint Authors
Song, Kai
Li, Qian
Yin, Xiao-Ya
Lu, Ying
Liu, Chun-Feng
Hu, Li-Fang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Fibrotic diseases including chronic kidney disease, liver cirrhosis, idiopathic pulmonary fibrosis, and chronic disease account for 45% mortality in the developed countries and pose a great threat to the global health.
Many great targets and molecules have been reported to be involved in the initiation and/or progression of fibrosis, among which inflammation and oxidative stress are well-recognized modulation targets.
Hydrogen sulfide (H2S) is the third gasotransmitter with potent properties in inhibiting inflammation and oxidative stress in various organs.
Recent evidence suggests that plasma H2S level is decreased in various animal models of fibrotic diseases and supplement of exogenous H2S is able to ameliorate fibrosis in the kidney, lung, liver, and heart.
This leads us to propose that modulation of H2S production may represent a promising therapeutic venue for the treatment of a variety of fibrotic diseases.
Here, we summarize and discuss the current data on the role and underlying mechanisms of H2S in fibrosis diseases related to heart, liver, kidney, and other organs.
American Psychological Association (APA)
Song, Kai& Li, Qian& Yin, Xiao-Ya& Lu, Ying& Liu, Chun-Feng& Hu, Li-Fang. 2015. Hydrogen Sulfide: A Therapeutic Candidate for Fibrotic Disease?. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075659
Modern Language Association (MLA)
Song, Kai…[et al.]. Hydrogen Sulfide: A Therapeutic Candidate for Fibrotic Disease?. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075659
American Medical Association (AMA)
Song, Kai& Li, Qian& Yin, Xiao-Ya& Lu, Ying& Liu, Chun-Feng& Hu, Li-Fang. Hydrogen Sulfide: A Therapeutic Candidate for Fibrotic Disease?. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075659