Increased Clearance of Reactive Aldehydes and Damaged Proteins in Hypertension-Induced Compensated Cardiac Hypertrophy: Impact of Exercise Training
Joint Authors
Campos, Juliane Cruz
Fernandes, Tiago
Paixão, Nathalie Alves da
Brum, Patricia Chakur
Oliveira, Edilamar Menezes de
Ferreira, Julio Cesar Batista
Bechara, Luiz Roberto Grassmann
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
We previously reported that exercise training (ET) facilitates the clearance of damaged proteins in heart failure.
Here, we characterized the impact of ET on cardiac protein quality control during compensated ventricular hypertrophy in spontaneously hypertensive rats (SHR).
Methods and Results.
SHR were randomly assigned into sedentary and swimming-trained groups.
Sedentary SHR displayed cardiac hypertrophy with preserved ventricular function compared to normotensive rats, characterizing a compensated cardiac hypertrophy.
Hypertensive rats presented signs of cardiac oxidative stress, depicted by increased lipid peroxidation.
However, these changes were not followed by accumulation of lipid peroxidation-generated reactive aldehydes and damaged proteins.
This scenario was explained, at least in part, by the increased catalytic activity of both aldehyde dehydrogenase 2 (ALDH2) and proteasome.
Of interest, ET exacerbated cardiac hypertrophy, improved ventricular function, induced resting bradycardia, and decreased blood pressure in SHR.
These changes were accompanied by reduced cardiac oxidative stress and a consequent decrease in ALDH2 and proteasome activities, without affecting small chaperones levels and apoptosis in SHR.
Conclusion.
Increased cardiac ALDH2 and proteasomal activities counteract the deleterious effect of excessive oxidative stress in hypertension-induced compensated cardiac hypertrophy in rats.
ET has a positive effect in reducing cardiac oxidative stress without affecting protein quality control.
American Psychological Association (APA)
Campos, Juliane Cruz& Fernandes, Tiago& Bechara, Luiz Roberto Grassmann& Paixão, Nathalie Alves da& Brum, Patricia Chakur& Oliveira, Edilamar Menezes de…[et al.]. 2015. Increased Clearance of Reactive Aldehydes and Damaged Proteins in Hypertension-Induced Compensated Cardiac Hypertrophy: Impact of Exercise Training. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075661
Modern Language Association (MLA)
Campos, Juliane Cruz…[et al.]. Increased Clearance of Reactive Aldehydes and Damaged Proteins in Hypertension-Induced Compensated Cardiac Hypertrophy: Impact of Exercise Training. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075661
American Medical Association (AMA)
Campos, Juliane Cruz& Fernandes, Tiago& Bechara, Luiz Roberto Grassmann& Paixão, Nathalie Alves da& Brum, Patricia Chakur& Oliveira, Edilamar Menezes de…[et al.]. Increased Clearance of Reactive Aldehydes and Damaged Proteins in Hypertension-Induced Compensated Cardiac Hypertrophy: Impact of Exercise Training. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075661
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075661