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Antioxidative Diet Supplementation Reverses High-Fat Diet-Induced Increases of Cardiovascular Risk Factors in Mice
Joint Authors
Schnoor, Michael
Vargas-Robles, Hilda
Rios, Amelia
Arellano-Mendoza, Monica
Escalante, Bruno A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Obesity is a worldwide epidemic that is characterized not only by excessive fat deposition but also by systemic microinflammation, high oxidative stress, and increased cardiovascular risk factors.
While diets enriched in natural antioxidants showed beneficial effects on oxidative stress, blood pressure, and serum lipid composition, diet supplementation with synthetic antioxidants showed contradictive results.
Thus, we tested in C57Bl/6 mice whether a daily dosage of an antioxidative mixture consisting of vitamin C, vitamin E, L-arginine, eicosapentaenoic acid, and docosahexaenoic acid (corabion) would affect cardiovascular risk factors associated with obesity.
Obese mice showed increased serum triglyceride and glucose levels and hypertension after eight weeks of being fed a high-fat diet (HFD).
Importantly, corabion ameliorated all of these symptoms significantly.
Oxidative stress and early signs of systemic microinflammation already developed after two weeks of high-fat diet and were significantly reduced by daily doses of corabion.
Of note, the beneficial effects of corabion could not be observed when applying its single antioxidative components suggesting that a combination of various nutrients is required to counteract HFD-induced cardiovascular risk factors.
Thus, daily consumption of corabion may be beneficial for the management of obesity-related cardiovascular complications.
American Psychological Association (APA)
Vargas-Robles, Hilda& Rios, Amelia& Arellano-Mendoza, Monica& Escalante, Bruno A.& Schnoor, Michael. 2015. Antioxidative Diet Supplementation Reverses High-Fat Diet-Induced Increases of Cardiovascular Risk Factors in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075662
Modern Language Association (MLA)
Vargas-Robles, Hilda…[et al.]. Antioxidative Diet Supplementation Reverses High-Fat Diet-Induced Increases of Cardiovascular Risk Factors in Mice. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1075662
American Medical Association (AMA)
Vargas-Robles, Hilda& Rios, Amelia& Arellano-Mendoza, Monica& Escalante, Bruno A.& Schnoor, Michael. Antioxidative Diet Supplementation Reverses High-Fat Diet-Induced Increases of Cardiovascular Risk Factors in Mice. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075662