miR-103 Regulates Oxidative Stress by Targeting the BCL2Adenovirus E1B 19 kDa Interacting Protein 3 in HUVECs
Joint Authors
Xu, Mao-Chun
Gao, Xiu-Fang
Ruan, Changwu
Ge, Zhi-Ru
Lu, Ji-De
Zhang, Jian-Jun
Zhang, Yu
Wang, Lu
Shi, Hai-Ming
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Oxidative stress plays a critical role in cardiovascular diseases.
Salidroside, a glycoside from Rhodiola rosea, has been used as an antioxidative therapy for oxidative injury in cardiac diseases.
However, the mechanism underlying its antioxidant effect needs to be elucidated.
Treatment of HUVECs with H2O2 significantly decreased the expression of miR-103 in a dose- and time-dependent manner, whereas pretreatment with salidroside significantly inhibited this decrease.
Subsequent analysis showed that overexpression of miR-103 abrogated cell activity and ROS production induced by H2O2.
Bcl2/adenovirus E1B 19 kDa interacting protein 3 (BNIP3) was determined to be a novel miR-103 target in HUVECs.
Interestingly, H2O2 treatment upregulated BNIP3 expression; in turn, this effect was inhibited by pretreatment with salidroside.
Further studies confirmed that the knockdown of BNIP3 enhanced cell activity and suppressed the ROS production induced by H2O2.
These results demonstrated for the first time that salidroside protects HUVECs in part by upregulating the expression of miR-103, which mediates BNIP3 downregulation and plays an important role in the cytoprotective actions.
American Psychological Association (APA)
Xu, Mao-Chun& Gao, Xiu-Fang& Ruan, Changwu& Ge, Zhi-Ru& Lu, Ji-De& Zhang, Jian-Jun…[et al.]. 2015. miR-103 Regulates Oxidative Stress by Targeting the BCL2Adenovirus E1B 19 kDa Interacting Protein 3 in HUVECs. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075671
Modern Language Association (MLA)
Xu, Mao-Chun…[et al.]. miR-103 Regulates Oxidative Stress by Targeting the BCL2Adenovirus E1B 19 kDa Interacting Protein 3 in HUVECs. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075671
American Medical Association (AMA)
Xu, Mao-Chun& Gao, Xiu-Fang& Ruan, Changwu& Ge, Zhi-Ru& Lu, Ji-De& Zhang, Jian-Jun…[et al.]. miR-103 Regulates Oxidative Stress by Targeting the BCL2Adenovirus E1B 19 kDa Interacting Protein 3 in HUVECs. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075671