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Oxidative Stress State Is Associated with Left Ventricular Mechanics Changes, Measured by Speckle Tracking in Essential Hypertensive Patients
Joint Authors
Maldonado, Perla D.
Rodríguez-Martínez, Erika
Rivas-Arancibia, Selva
Moreno-Ruíz, Luis Antonio
Ibarra-Quevedo, David
Sarabia-Ortega, Benito
Hernández-Martínez, José Gustavo
Espinosa-Caleti, Beda
Mendoza-Pérez, Beatriz
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The oxidative stress state is characterized by an increase in oxygen reactive species that overwhelms the antioxidant defense; we do not know if these pathological changes are correlated with alterations in left ventricular mechanics.
The aim was correlating the oxidative stress state with the left ventricular global longitudinal strain (GLS) and the left ventricular end diastolic pressure (LVEDP).
Twenty-five patients with essential hypertension and 25 controls paired by age and gender were studied.
All of the participants were subjected to echocardiography and biochemical determination of oxidative stress markers.
The hypertensive patients, compared with control subjects, had significantly (p<0.05) higher levels of oxidized proteins (5.03±1.05 versus 4.06±0.63 nmol/mg), lower levels of extracellular superoxide dismutase (EC-SOD) activity (0.045±0.02 versus 0.082±0.02 U/mg), higher LVEDP (16.2±4.5 versus 11.3±1.6 mm Hg), and lower GLS (−12% versus −16%).
Both groups had preserved ejection fraction and the results showed a positive correlation of oxidized proteins with GLS (r=0.386, p=0.006) and LVEDP (r=0.389, p=0.005); we also found a negative correlation of EC-SOD activity with GLS (r=-0.404, p=0.004) and LVEDP (r=-0.347, p=0.014).
American Psychological Association (APA)
Moreno-Ruíz, Luis Antonio& Ibarra-Quevedo, David& Rodríguez-Martínez, Erika& Maldonado, Perla D.& Sarabia-Ortega, Benito& Hernández-Martínez, José Gustavo…[et al.]. 2015. Oxidative Stress State Is Associated with Left Ventricular Mechanics Changes, Measured by Speckle Tracking in Essential Hypertensive Patients. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075677
Modern Language Association (MLA)
Moreno-Ruíz, Luis Antonio…[et al.]. Oxidative Stress State Is Associated with Left Ventricular Mechanics Changes, Measured by Speckle Tracking in Essential Hypertensive Patients. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075677
American Medical Association (AMA)
Moreno-Ruíz, Luis Antonio& Ibarra-Quevedo, David& Rodríguez-Martínez, Erika& Maldonado, Perla D.& Sarabia-Ortega, Benito& Hernández-Martínez, José Gustavo…[et al.]. Oxidative Stress State Is Associated with Left Ventricular Mechanics Changes, Measured by Speckle Tracking in Essential Hypertensive Patients. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075677