Neuroprotective Effect of Dexmedetomidine on Hyperoxia-Induced Toxicity in the Neonatal Rat Brain
Joint Authors
Spies, Claudia D.
Sifringer, Marco
Bührer, Christoph
von Haefen, Clarissa
Krain, Maria
Paeschke, Nadine
Bendix, Ivo
Endesfelder, Stefanie
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Dexmedetomidine is a highly selective agonist of α2-receptors with sedative, anxiolytic, analgesic, and anesthetic properties.
Neuroprotective effects of dexmedetomidine have been reported in various brain injury models.
In the present study, we investigated the effects of dexmedetomidine on neurodegeneration, oxidative stress markers, and inflammation following the induction of hyperoxia in neonatal rats.
Six-day-old Wistar rats received different concentrations of dexmedetomidine (1, 5, or 10 µg/kg bodyweight) and were exposed to 80% oxygen for 24 h.
Sex-matched littermates kept in room air and injected with normal saline or dexmedetomidine served as controls.
Dexmedetomidine pretreatment significantly reduced hyperoxia-induced neurodegeneration in different brain regions of the neonatal rat.
In addition, dexmedetomidine restored the reduced/oxidized glutathione ratio and attenuated the levels of malondialdehyde, a marker of lipid peroxidation, after exposure to high oxygen concentration.
Moreover, administration of dexmedetomidine induced downregulation of IL-1β on mRNA and protein level in the developing rat brain.
Dexmedetomidine provides protections against toxic oxygen induced neonatal brain injury which is likely associated with oxidative stress signaling and inflammatory cytokines.
Our results suggest that dexmedetomidine may have a therapeutic potential since oxygen administration to neonates is sometimes inevitable.
American Psychological Association (APA)
Sifringer, Marco& von Haefen, Clarissa& Krain, Maria& Paeschke, Nadine& Bendix, Ivo& Bührer, Christoph…[et al.]. 2015. Neuroprotective Effect of Dexmedetomidine on Hyperoxia-Induced Toxicity in the Neonatal Rat Brain. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075683
Modern Language Association (MLA)
Sifringer, Marco…[et al.]. Neuroprotective Effect of Dexmedetomidine on Hyperoxia-Induced Toxicity in the Neonatal Rat Brain. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075683
American Medical Association (AMA)
Sifringer, Marco& von Haefen, Clarissa& Krain, Maria& Paeschke, Nadine& Bendix, Ivo& Bührer, Christoph…[et al.]. Neuroprotective Effect of Dexmedetomidine on Hyperoxia-Induced Toxicity in the Neonatal Rat Brain. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075683
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075683