NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species
Joint Authors
Ghosh, Rajeshwary
Alajbegovic, Azra
Gomes, Aldrin V.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-20
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs worldwide.
NSAIDs are used for a variety of conditions including pain, rheumatoid arthritis, and musculoskeletal disorders.
The beneficial effects of NSAIDs in reducing or relieving pain are well established, and other benefits such as reducing inflammation and anticancer effects are also documented.
The undesirable side effects of NSAIDs include ulcers, internal bleeding, kidney failure, and increased risk of heart attack and stroke.
Some of these side effects may be due to the oxidative stress induced by NSAIDs in different tissues.
NSAIDs have been shown to induce reactive oxygen species (ROS) in different cell types including cardiac and cardiovascular related cells.
Increases in ROS result in increased levels of oxidized proteins which alters key intracellular signaling pathways.
One of these key pathways is apoptosis which causes cell death when significantly activated.
This review discusses the relationship between NSAIDs and cardiovascular diseases (CVD) and the role of NSAID-induced ROS in CVD.
American Psychological Association (APA)
Ghosh, Rajeshwary& Alajbegovic, Azra& Gomes, Aldrin V.. 2015. NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-25.
https://search.emarefa.net/detail/BIM-1075687
Modern Language Association (MLA)
Ghosh, Rajeshwary…[et al.]. NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-25.
https://search.emarefa.net/detail/BIM-1075687
American Medical Association (AMA)
Ghosh, Rajeshwary& Alajbegovic, Azra& Gomes, Aldrin V.. NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-25.
https://search.emarefa.net/detail/BIM-1075687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075687