Treatment of β-ThalassemiaHemoglobin E with Antioxidant Cocktails Results in Decreased Oxidative Stress, Increased Hemoglobin Concentration, and Improvement of the Hypercoagulable State
Joint Authors
Kalpravidh, Ruchaneekorn W.
Hatairaktham, Suneerat
Charoensakdi, Ratiya
Panichkul, Narumol
Siritanaratkul, Noppadol
Yanpanitch, Orn-uma
Fucharoen, Suthat
Srichairatanakool, Somdet
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Studies on the antioxidant treatment for thalassemia have reported variable outcomes.
However, treatment of thalassemia with a combination of hydrophobic and hydrophilic antioxidants and an iron chelator has not been studied.
This study investigated the effects of antioxidant cocktails for the treatment of β-thalassemia/hemoglobin E (HbE), which is the most common form of β-thalassemia in Southeast Asia.
Sixty patients were divided into two groups receiving N-acetylcysteine, deferiprone, and either curcuminoids (CUR) or vitamin E (Vit-E), and their hematological parameters, iron load, oxidative stress, and blood coagulation potential were evaluated.
Patients were classified as responders if they showed the improvements of the markers of iron load and oxidative stress, otherwise as nonresponders.
During treatment, the responders in both groups had significantly decreased iron load, oxidative stress, and coagulation potential and significantly increased antioxidant capacity and hemoglobin concentration.
The significantly maximum increase (P<0.01) in hemoglobin concentration was 11% at month 4 in CUR group responders and 10% at month 10 in Vit-E group responders.
In conclusion, the two antioxidant cocktails can improve anemia, iron overload, oxidative stress, and hypercoagulable state in β-thalassemia/HbE.
American Psychological Association (APA)
Yanpanitch, Orn-uma& Hatairaktham, Suneerat& Charoensakdi, Ratiya& Panichkul, Narumol& Fucharoen, Suthat& Srichairatanakool, Somdet…[et al.]. 2015. Treatment of β-ThalassemiaHemoglobin E with Antioxidant Cocktails Results in Decreased Oxidative Stress, Increased Hemoglobin Concentration, and Improvement of the Hypercoagulable State. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075688
Modern Language Association (MLA)
Yanpanitch, Orn-uma…[et al.]. Treatment of β-ThalassemiaHemoglobin E with Antioxidant Cocktails Results in Decreased Oxidative Stress, Increased Hemoglobin Concentration, and Improvement of the Hypercoagulable State. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075688
American Medical Association (AMA)
Yanpanitch, Orn-uma& Hatairaktham, Suneerat& Charoensakdi, Ratiya& Panichkul, Narumol& Fucharoen, Suthat& Srichairatanakool, Somdet…[et al.]. Treatment of β-ThalassemiaHemoglobin E with Antioxidant Cocktails Results in Decreased Oxidative Stress, Increased Hemoglobin Concentration, and Improvement of the Hypercoagulable State. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075688
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075688