Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns
Joint Authors
Marseglia, Lucia
Manti, Sara
Caccamo, Daniela
Alibrandi, Angela
Nicotera, Antonio
Salpietro, Vincenzo
Giaimo, Elisa
Cardile, Giovanna
Bonsignore, Maria
D’Angelo, Gabriella
Mamì, Carmelo
Di Rosa, Gabriella
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Higher total homocysteine (tHcy) levels, and C677T and A1298C methylenetetrahydrofolate (MTHFR) polymorphisms, have been reported in preterm or full term newborns with neonatal encephalopathy following perinatal hypoxic-ischemic insult.
This study investigated the causal role of tHcy and MTHFR polymorphisms together with other acquired risk factors on the occurrence of brain white matter abnormalities (WMA) detected by cranial ultrasound scans (cUS) in a population of late preterm and full term infants.
A total of 171 newborns (81 M, 47.4%), 45 (26.3%) born <37 wks, and 126 (73.7%) born ≥37 wks were recruited in the study.
cUS detected predominant WMA pattern in 36/171 newborns (21.1%) mainly characterized by abnormal periventricular white matter signal and mild-to-moderate periventricular white matter volume loss with ventricular dilatation (6/36, 16.6%).
WMA resulted in being depending on tHcy levels ( P < 0.014 ) , lower GA ( P < 0.000 ) , lower Apgar score at 1 minutes ( P < 0.000 ) and 5 minutes ( P < 0.000 ) , and 1298AC and 677CT/1298AC genotypes ( P < 0.000 and P < 0.000 ).
In conclusion, both acquired and genetic predisposing antenatal factors were significantly associated with adverse neonatal outcome and WMA.
The role of A1298C polymorphism may be taken into account for prenatal assessment and treatment counseling.
American Psychological Association (APA)
Marseglia, Lucia& Nicotera, Antonio& Salpietro, Vincenzo& Giaimo, Elisa& Cardile, Giovanna& Bonsignore, Maria…[et al.]. 2015. Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075690
Modern Language Association (MLA)
Marseglia, Lucia…[et al.]. Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075690
American Medical Association (AMA)
Marseglia, Lucia& Nicotera, Antonio& Salpietro, Vincenzo& Giaimo, Elisa& Cardile, Giovanna& Bonsignore, Maria…[et al.]. Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075690
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075690