Hydrogen Sulfide as a Potential Therapeutic Target in Fibrosis
Joint Authors
Zhang, Shufang
Pan, Chuli
Zhou, Feifei
Yuan, Zhi
Wang, Huiying
Cui, Wei
Zhang, Gensheng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Hydrogen sulfide (H2S), produced endogenously by the activation of two major H2S-generating enzymes (cystathionine β-synthase and cystathionine γ-lyase), plays important regulatory roles in different physiologic and pathologic conditions.
The abnormal metabolism of H2S is associated with fibrosis pathogenesis, causing damage in structure and function of different organs.
A number of in vivo and in vitro studies have shown that both endogenous H2S level and the expressions of H2S-generating enzymes in plasma and tissues are significantly downregulated during fibrosis.
Supplement with exogenous H2S mitigates the severity of fibrosis in various experimental animal models.
The protective role of H2S in the development of fibrosis is primarily attributed to its antioxidation, antiapoptosis, anti-inflammation, proangiogenesis, and inhibition of fibroblasts activities.
Future studies might focus on the potential to intervene fibrosis by targeting the pathway of endogenous H2S-producing enzymes and H2S itself.
American Psychological Association (APA)
Zhang, Shufang& Pan, Chuli& Zhou, Feifei& Yuan, Zhi& Wang, Huiying& Cui, Wei…[et al.]. 2015. Hydrogen Sulfide as a Potential Therapeutic Target in Fibrosis. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075699
Modern Language Association (MLA)
Zhang, Shufang…[et al.]. Hydrogen Sulfide as a Potential Therapeutic Target in Fibrosis. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075699
American Medical Association (AMA)
Zhang, Shufang& Pan, Chuli& Zhou, Feifei& Yuan, Zhi& Wang, Huiying& Cui, Wei…[et al.]. Hydrogen Sulfide as a Potential Therapeutic Target in Fibrosis. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075699
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075699