Association of the Apolipoprotein E 2 Allele with Concurrent Occurrence of Endometrial Hyperplasia and Endometrial Carcinoma
Joint Authors
Salnikova, Lyubov E.
Ivanova, Tatiana I.
Krikunova, Ludmila I.
Ryabchenko, Nikolay I.
Mkrtchyan, Liana S.
Khorokhorina, Vera A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Genes encoding proteins with antioxidant properties may influence susceptibility to endometrial hyperplasia (EH) and endometrial carcinoma (ECa).
Patients with EH (n = 89), EH concurrent with ECa (n = 76), ECa (n = 186), and healthy controls (n = 1110) were genotyped for five polymorphic variants in the genes involved in metabolism of lipoproteins (APOE Cys112Arg and Arg158Cys), iron (HFE Cys282Tyr and His63Asp), and catecholamines (COMT Val158Met).
Patients and controls were matched by ethnicity (all Caucasians), age, body mass index (BMI), and incidence of hypertension and diabetes.
The frequency of the APOE E 2 allele (158Cys) was higher in patients with EH + ECa than in controls (P = 0.0012, P Bonferroni = 0.018, OR = 2.58, 95% CI 1.49–4.45).
The APOE E 4 allele (112Arg) was more frequently found in patients with EH than in controls and HFE minor allele G (63Asp) had a protective effect in the ECa group, though these results appeared to be nonsignificant after correction for multiple comparisons.
The results of the study indicate that E 2 allele might be associated with concurrent occurrence of EH and ECa.
American Psychological Association (APA)
Ivanova, Tatiana I.& Krikunova, Ludmila I.& Ryabchenko, Nikolay I.& Mkrtchyan, Liana S.& Khorokhorina, Vera A.& Salnikova, Lyubov E.. 2015. Association of the Apolipoprotein E 2 Allele with Concurrent Occurrence of Endometrial Hyperplasia and Endometrial Carcinoma. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075700
Modern Language Association (MLA)
Ivanova, Tatiana I.…[et al.]. Association of the Apolipoprotein E 2 Allele with Concurrent Occurrence of Endometrial Hyperplasia and Endometrial Carcinoma. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075700
American Medical Association (AMA)
Ivanova, Tatiana I.& Krikunova, Ludmila I.& Ryabchenko, Nikolay I.& Mkrtchyan, Liana S.& Khorokhorina, Vera A.& Salnikova, Lyubov E.. Association of the Apolipoprotein E 2 Allele with Concurrent Occurrence of Endometrial Hyperplasia and Endometrial Carcinoma. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075700
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075700