The Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid-β Production in Alzheimer’s Disease
Joint Authors
Chuang, Chia-Chen
Zuo, Li
Hemmelgarn, Benjamin T.
Best, Thomas M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
An increasing number of studies have proposed a strong correlation between reactive oxygen species (ROS)-induced oxidative stress (OS) and the pathogenesis of Alzheimer’s disease (AD).
With over five million people diagnosed in the United States alone, AD is the most common type of dementia worldwide.
AD includes progressive neurodegeneration, followed by memory loss and reduced cognitive ability.
Characterized by the formation of amyloid-beta (Aβ) plaques as a hallmark, the connection between ROS and AD is compelling.
Analyzing the ROS response of essential proteins in the amyloidogenic pathway, such as amyloid-beta precursor protein (APP) and beta-secretase (BACE1), along with influential signaling programs of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and c-Jun N-terminal kinase (JNK), has helped visualize the path between OS and Aβ overproduction.
In this review, attention will be paid to significant advances in the area of OS, epigenetics, and their influence on Aβ plaque assembly.
Additionally, we aim to discuss available treatment options for AD that include antioxidant supplements, Asian traditional medicines, metal-protein-attenuating compounds, and histone modifying inhibitors.
American Psychological Association (APA)
Zuo, Li& Hemmelgarn, Benjamin T.& Chuang, Chia-Chen& Best, Thomas M.. 2015. The Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid-β Production in Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075704
Modern Language Association (MLA)
Zuo, Li…[et al.]. The Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid-β Production in Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1075704
American Medical Association (AMA)
Zuo, Li& Hemmelgarn, Benjamin T.& Chuang, Chia-Chen& Best, Thomas M.. The Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid-β Production in Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075704
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075704