Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury
Joint Authors
Lee, Simon Ming-Yuen
Zhang, Zai Jun
Zhou, Xinhua
Zhu, Longjun
Wang, Liang
Guo, Baojian
Zhang, Gaoxiao
Sun, Yewei
Yu, Pei
Wang, Yuqiang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Edaravone (EDA) is clinically used for treatment of acute ischemic stroke in Japan and China due to its potent free radical-scavenging effect.
However, it has yet to be determined whether EDA can attenuate iodoacetic acid- (IAA-) induced neuronal death in vitro.
In the present study, we investigated the effect of EDA on damage of IAA-induced primary cerebellar granule neurons (CGNs) and its possible underlying mechanisms.
We found that EDA attenuated IAA-induced cell injury in CGNs.
Moreover, EDA significantly reduced intracellular reactive oxidative stress production, loss of mitochondrial membrane potential, and caspase 3 activity induced by IAA.
Taken together, EDA protected CGNs against IAA-induced neuronal damage, which may be attributed to its antiapoptotic and antioxidative activities.
American Psychological Association (APA)
Zhou, Xinhua& Zhu, Longjun& Wang, Liang& Guo, Baojian& Zhang, Gaoxiao& Sun, Yewei…[et al.]. 2015. Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075707
Modern Language Association (MLA)
Zhou, Xinhua…[et al.]. Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075707
American Medical Association (AMA)
Zhou, Xinhua& Zhu, Longjun& Wang, Liang& Guo, Baojian& Zhang, Gaoxiao& Sun, Yewei…[et al.]. Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075707
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075707