An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells
Joint Authors
Tian, Ye
Zhang, Li
Xu, Changqing
Wang, Rui
Qi, Qi
Yang, Jianqiang
Sun, Dongsheng
Li, Chunfeng
Xue, Yingwei
Jiang, Qiuying
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hydrogen sulfide (H2S) can be synthesized in mammalian cells by cystathionine γ-lyase (CSE) and/or cystathionine β-synthase (CBS).
Both CSE and CBS are expressed in rat gastric tissues but their role in human gastric neoplasia has been unclear.
The aims of the present study were to detect CSE and CBS proteins in human gastric cancer and determine the effect of exogenous NaHS on the proliferation of gastric cancer cells.
We found that both CSE and CBS proteins were expressed in human gastric cancer cells and upregulated in human gastric carcinoma mucosa compared with those in noncancerous gastric samples.
NaHS induced apoptosis of gastric cancer cells by regulating apoptosis related proteins.
Also, NaHS inhibited cancer cell migration and invasion.
An antigastric cancer role of H2S is thus indicated.
American Psychological Association (APA)
Zhang, Li& Qi, Qi& Yang, Jianqiang& Sun, Dongsheng& Li, Chunfeng& Xue, Yingwei…[et al.]. 2015. An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075721
Modern Language Association (MLA)
Zhang, Li…[et al.]. An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075721
American Medical Association (AMA)
Zhang, Li& Qi, Qi& Yang, Jianqiang& Sun, Dongsheng& Li, Chunfeng& Xue, Yingwei…[et al.]. An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075721
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075721
