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Role of the Lipoperoxidation Product 4-Hydroxynonenal in the Pathogenesis of Severe Malaria Anemia and Malaria Immunodepression
Joint Authors
Schwarzer, Evelin
Arese, Paolo
Skorokhod, Oleksii A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Oxidative stress plays an important role in the pathogenesis of falciparum malaria, a disease still claiming close to 1 million deaths and 200 million new cases per year.
Most frequent complications are severe anemia, cerebral malaria, and immunodepression, the latter being constantly present in all forms of malaria.
Complications are associated with oxidative stress and lipoperoxidation.
Its final product 4-hydroxynonenal (4-HNE), a stable yet very reactive and diffusible molecule, forms covalent conjugates with proteins, DNA, and phospholipids and modulates important cell functions at very low concentrations.
Since oxidative stress plays important roles in the pathogenesis of severe malaria, it appears important to explore the role of 4-HNE in two important malaria complications such as malaria anemia and malaria immunodepression where oxidative stress is considered to be involved.
In this review we will summarize data about 4-HNE chemistry, its biologically relevant chemical properties, and its role as regulator of physiologic processes and as pathogenic factor.
We will review studies documenting the role of 4-HNE in severe malaria with emphasis on malaria anemia and immunodepression.
Data from other diseases qualify 4-HNE both as oxidative stress marker and as pathomechanistically important molecule.
Further studies are needed to establish 4-HNE as accepted pathogenic factor in severe malaria.
American Psychological Association (APA)
Schwarzer, Evelin& Arese, Paolo& Skorokhod, Oleksii A.. 2015. Role of the Lipoperoxidation Product 4-Hydroxynonenal in the Pathogenesis of Severe Malaria Anemia and Malaria Immunodepression. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075722
Modern Language Association (MLA)
Schwarzer, Evelin…[et al.]. Role of the Lipoperoxidation Product 4-Hydroxynonenal in the Pathogenesis of Severe Malaria Anemia and Malaria Immunodepression. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075722
American Medical Association (AMA)
Schwarzer, Evelin& Arese, Paolo& Skorokhod, Oleksii A.. Role of the Lipoperoxidation Product 4-Hydroxynonenal in the Pathogenesis of Severe Malaria Anemia and Malaria Immunodepression. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075722