Quercetin Affects Hsp70IRE1α Mediated Protection from Death Induced by Endoplasmic Reticulum Stress
Joint Authors
Storniolo, Antonello
Raciti, Marisa
Di Renzo, Livia
Cucina, Alessandra
Bizzarri, Mariano
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Relative to their normal counterparts, tumor cells generally exhibit a greater “stress phenotype” and express heat shock proteins (Hsp) that represent candidate targets for anticancer therapy.
Here we investigated the role of Hsp70 in survival induced by endoplasmic reticulum (ER) stressors in human leukemia U937 cells.
Quercetin, a major dietary flavonoid, or specific silencing affected the expression level of Hsp70 and did not allow the upregulation of inositol-requiring kinase 1α (IRE1α), the prototype ER stress sensor regulating the unfolded protein response (UPR), that protects the cells against the stress of misfolded proteins in the ER.
The reduction of Hsp70 prevented the upregulation of immunoglobulin heavy-chain binding protein (BiP), but not of CCAAT/enhancer-binding protein-homologous protein (CHOP), and induced apoptosis.
Also specific silencing of IRE1α or inhibition of its endoribonuclease activity by 4μ8c hampered the upregulation of BiP, but not of CHOP, and induced apoptosis.
These results suggest that drugs affecting the Hsp70-IRE1α axis, like quercetin, or affecting directly IRE1α may represent an effective adjuvant antileukemia therapy.
American Psychological Association (APA)
Storniolo, Antonello& Raciti, Marisa& Cucina, Alessandra& Bizzarri, Mariano& Di Renzo, Livia. 2015. Quercetin Affects Hsp70IRE1α Mediated Protection from Death Induced by Endoplasmic Reticulum Stress. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075724
Modern Language Association (MLA)
Storniolo, Antonello…[et al.]. Quercetin Affects Hsp70IRE1α Mediated Protection from Death Induced by Endoplasmic Reticulum Stress. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075724
American Medical Association (AMA)
Storniolo, Antonello& Raciti, Marisa& Cucina, Alessandra& Bizzarri, Mariano& Di Renzo, Livia. Quercetin Affects Hsp70IRE1α Mediated Protection from Death Induced by Endoplasmic Reticulum Stress. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075724