Total Glucosides of Danggui Buxue Tang Attenuate BLM-Induced Pulmonary Fibrosis via Regulating Oxidative Stress by Inhibiting NOX4
Joint Authors
Zhao, Ping
Zhou, Wen-Cheng
Li, De-Lin
Mo, Xiao-Ting
Xu, Liang
Li, Liu-Cheng
Cui, Wen-Hui
Gao, Jian
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Pulmonary fibrosis (PF) is a serious chronic lung disease with unknown pathogenesis.
Researches have confirmed that oxidative stress which is regulated by NADPH oxidase-4 (NOX4), a main source of reactive oxygen species (ROS), is an important molecular mechanism underlying PF.
Previous studies showed that total glucosides of Danggui Buxue Tang (DBTG), an extract from a classical traditional Chinese herbal formula, Danggui Buxue Tang (DBT), attenuated bleomycin-induced PF in rats.
However, the mechanisms of DBTG are still not clear.
We hypothesize that DBTG attenuates PF through regulating the level of oxidative stress by inhibiting NOX4.
And we found that fibrosis indexes hydroxyproline (HYP) and type I collagen (Col-I) were lower in DBTG groups compared with the model group.
In addition, the expression of transforming growth factor-β1 (TGF-β1) and expression of alpha smooth muscle actin (α-SMA) were also much more decreased than the model group.
For oxidative stress indicators, DBTG blunted the decrease of superoxide dismutase (SOD) activity, total antioxidant capacity (T-AOC), and the increase in malondialdehyde (MDA), 8-iso-prostaglandin in lung homogenates.
Treatment with DBTG restrained the expression of NOX4 compared to the model group.
Present study confirms that DBTG inhibits BLM-induced PF by modulating the level of oxidative stress via suppressing NOX4.
American Psychological Association (APA)
Zhao, Ping& Zhou, Wen-Cheng& Li, De-Lin& Mo, Xiao-Ting& Xu, Liang& Li, Liu-Cheng…[et al.]. 2015. Total Glucosides of Danggui Buxue Tang Attenuate BLM-Induced Pulmonary Fibrosis via Regulating Oxidative Stress by Inhibiting NOX4. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075725
Modern Language Association (MLA)
Zhao, Ping…[et al.]. Total Glucosides of Danggui Buxue Tang Attenuate BLM-Induced Pulmonary Fibrosis via Regulating Oxidative Stress by Inhibiting NOX4. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075725
American Medical Association (AMA)
Zhao, Ping& Zhou, Wen-Cheng& Li, De-Lin& Mo, Xiao-Ting& Xu, Liang& Li, Liu-Cheng…[et al.]. Total Glucosides of Danggui Buxue Tang Attenuate BLM-Induced Pulmonary Fibrosis via Regulating Oxidative Stress by Inhibiting NOX4. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075725