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Sirtuin Functions in Female Fertility: Possible Role in Oxidative Stress and Aging
Joint Authors
Di Emidio, Giovanna
Vitti, Maurizio
Di Carlo, Michela
Santini, Silvano
D’Alessandro, Anna Maria
Falone, Stefano
Amicarelli, Fernanda
Tatone, Carla
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In search for strategies aimed at preventing oxidative threat to female fertility, a possible role of sirtuins has emerged.
Sirtuins (silent information regulator 2 (Sir2) proteins), NAD+ dependent enzymes with deacetylase and/or mono-ADP-ribosyltransferase activity, are emerging as key antiaging molecules and regulators in many diseases.
Recently, a crucial role for SIRT1 and SIRT3, the main components of sirtuin family, as sensors and guardians of the redox state in oocytes, granulosa cells, and early embryos has emerged.
In this context, the aim of the present review is to summarize current knowledge from research papers on the role of sirtuins in female fertility with particular emphasis on the impairment of SIRT1 signalling with oocyte aging.
On this basis, the authors wish to build up a framework to promote research on the possible role of sirtuins as targets for future strategies for female fertility preservation.
American Psychological Association (APA)
Tatone, Carla& Di Emidio, Giovanna& Vitti, Maurizio& Di Carlo, Michela& Santini, Silvano& D’Alessandro, Anna Maria…[et al.]. 2015. Sirtuin Functions in Female Fertility: Possible Role in Oxidative Stress and Aging. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075729
Modern Language Association (MLA)
Tatone, Carla…[et al.]. Sirtuin Functions in Female Fertility: Possible Role in Oxidative Stress and Aging. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075729
American Medical Association (AMA)
Tatone, Carla& Di Emidio, Giovanna& Vitti, Maurizio& Di Carlo, Michela& Santini, Silvano& D’Alessandro, Anna Maria…[et al.]. Sirtuin Functions in Female Fertility: Possible Role in Oxidative Stress and Aging. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075729
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075729