Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models
Joint Authors
Hamilton, Karyn L.
Bruns, Danielle R.
Drake, Joshua C.
Biela, Laurie M.
Peelor, Frederick F.
Miller, Benjamin F.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Studying long-lived animals provides novel insight into shared characteristics of aging and represents a unique model to elucidate approaches to prevent chronic disease.
Oxidant stress underlies many chronic diseases and resistance to stress is a potential mechanism governing slowed aging.
The transcription factor nuclear factor (erythroid-derived 2)-like 2 is the “master regulator” of cellular antioxidant defenses.
Nrf2 is upregulated by some longevity promoting interventions and may play a role in regulating species longevity.
However, Nrf2 expression and activity in long-lived models have not been well described.
Here, we review evidence for altered Nrf2 signaling in a variety of slowed aging models that accomplish lifespan extension via pharmacological, nutritional, evolutionary, genetic, and presumably epigenetic means.
American Psychological Association (APA)
Bruns, Danielle R.& Drake, Joshua C.& Biela, Laurie M.& Peelor, Frederick F.& Miller, Benjamin F.& Hamilton, Karyn L.. 2015. Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1075752
Modern Language Association (MLA)
Bruns, Danielle R.…[et al.]. Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1075752
American Medical Association (AMA)
Bruns, Danielle R.& Drake, Joshua C.& Biela, Laurie M.& Peelor, Frederick F.& Miller, Benjamin F.& Hamilton, Karyn L.. Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1075752
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075752