Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans
Joint Authors
Guerra, Joyce Ferreira da Costa
Aparecida Paiva, Franciny
de Freitas Bonomo, Larissa
Ferreira Boasquivis, Patrícia
Borges Raposo de Paula, Igor Thadeu
Mendes Leal, Wagney
Silva, Marcelo Eustáquio
Pedrosa, Maria Lúcia
Oliveira, Riva de Paula
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-07
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Carqueja (Baccharis trimera) is a native plant found throughout South America.
Several studies have shown that Carqueja has antioxidant activity in vitro, as well as anti-inflammatory, antidiabetic, analgesic, antihepatotoxic, and antimutagenic properties.
However, studies regarding its antioxidant potential in vivo are limited.
In this study, we used Caenorhabditis elegans as a model to examine the antioxidant effects of a Carqueja hydroalcoholic extract (CHE) on stress resistance and lifespan and to investigate whether CHE has a protective effect in a C.
elegans model for Alzheimer's disease.
Here, we show for the first time, using in vivo assays, that CHE treatment improved oxidative stress resistance by increasing survival rate and by reducing ROS levels under oxidative stress conditions independently of the stress-related signaling pathways (p38, JNK, and ERK) and transcription factors (SKN-1/Nrf and DAF-16/Foxo) tested here.
CHE treatment also increased the defenses against β-amyloid toxicity in C.
elegans, in part by increasing proteasome activity and the expression of two heat shock protein genes.
Our findings suggest a potential neuroprotective use for Carqueja, supporting the idea that dietary antioxidants are a promising approach to boost the defensive systems against stress and neurodegeneration.
American Psychological Association (APA)
Aparecida Paiva, Franciny& de Freitas Bonomo, Larissa& Ferreira Boasquivis, Patrícia& Borges Raposo de Paula, Igor Thadeu& Guerra, Joyce Ferreira da Costa& Mendes Leal, Wagney…[et al.]. 2015. Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1075754
Modern Language Association (MLA)
Aparecida Paiva, Franciny…[et al.]. Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1075754
American Medical Association (AMA)
Aparecida Paiva, Franciny& de Freitas Bonomo, Larissa& Ferreira Boasquivis, Patrícia& Borges Raposo de Paula, Igor Thadeu& Guerra, Joyce Ferreira da Costa& Mendes Leal, Wagney…[et al.]. Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1075754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075754