Redox Regulation in Cancer Stem Cells
Joint Authors
Ding, Shijie
Li, Chunbao
Cheng, Ninghui
Cui, Xiaojiang
Xu, Xinglian
Zhou, Guanghong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Reactive oxygen species (ROS) and ROS-dependent (redox regulation) signaling pathways and transcriptional activities are thought to be critical in stem cell self-renewal and differentiation during growth and organogenesis.
Aberrant ROS burst and dysregulation of those ROS-dependent cellular processes are strongly associated with human diseases including many cancers.
ROS levels are elevated in cancer cells partially due to their higher metabolism rate.
In the past 15 years, the concept of cancer stem cells (CSCs) has been gaining ground as the subpopulation of cancer cells with stem cell-like properties and characteristics have been identified in various cancers.
CSCs possess low levels of ROS and are responsible for cancer recurrence after chemotherapy or radiotherapy.
Unfortunately, how CSCs control ROS production and scavenging and how ROS-dependent signaling pathways contribute to CSCs function remain poorly understood.
This review focuses on the role of redox balance, especially in ROS-dependent cellular processes in cancer stem cells (CSCs).
We updated recent advances in our understanding of ROS generation and elimination in CSCs and their effects on CSC self-renewal and differentiation through modulating signaling pathways and transcriptional activities.
The review concludes that targeting CSCs by manipulating ROS metabolism/dependent pathways may be an effective approach for improving cancer treatment.
American Psychological Association (APA)
Ding, Shijie& Li, Chunbao& Cheng, Ninghui& Cui, Xiaojiang& Xu, Xinglian& Zhou, Guanghong. 2015. Redox Regulation in Cancer Stem Cells. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075757
Modern Language Association (MLA)
Ding, Shijie…[et al.]. Redox Regulation in Cancer Stem Cells. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075757
American Medical Association (AMA)
Ding, Shijie& Li, Chunbao& Cheng, Ninghui& Cui, Xiaojiang& Xu, Xinglian& Zhou, Guanghong. Redox Regulation in Cancer Stem Cells. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075757
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075757