Interaction of Hydrogen Sulfide with Oxygen Sensing under Hypoxia
Joint Authors
Li, Hongzhu
Wu, Bo
Teng, Huajian
Zhang, Li
Li, Hong
Li, Jing
Wang, Lina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Based on the discovery of endogenous H2S production, many in depth studies show this gasotransmitter with a variety of physiological and pathological functions.
Three enzymes, cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MST), are involved in enzymatic production of H2S.
Emerging evidence has elucidated an important protective role of H2S in hypoxic conditions in many mammalian systems.
However, the mechanisms by which H2S senses and responses to hypoxia are largely elusive.
Hypoxia-inducible factors (HIFs) function as key regulators of oxygen sensing, activating target genes expression under hypoxia.
Recent studies have shown that exogenous H2S regulates HIF action in different patterns.
The activation of carotid bodies is a sensitive and prompt response to hypoxia, rapidly enhancing general O2 supply.
H2S has been identified as an excitatory mediator of hypoxic sensing in the carotid bodies.
This paper presents a brief review of the roles of these two pathways which contribute to hypoxic sensing of H2S.
American Psychological Association (APA)
Wu, Bo& Teng, Huajian& Zhang, Li& Li, Hong& Li, Jing& Wang, Lina…[et al.]. 2015. Interaction of Hydrogen Sulfide with Oxygen Sensing under Hypoxia. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075762
Modern Language Association (MLA)
Wu, Bo…[et al.]. Interaction of Hydrogen Sulfide with Oxygen Sensing under Hypoxia. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1075762
American Medical Association (AMA)
Wu, Bo& Teng, Huajian& Zhang, Li& Li, Hong& Li, Jing& Wang, Lina…[et al.]. Interaction of Hydrogen Sulfide with Oxygen Sensing under Hypoxia. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075762
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075762