Association of Age-Related Macular Degeneration with Erythrocyte Antioxidant Enzymes Activity and Serum Total Antioxidant Status
Joint Authors
Plestina-Borjan, Ivna
Katusic, Damir
Medvidovic-Grubisic, Maria
Supe-Domic, Daniela
Bucan, Kajo
Tandara, Leida
Rogosic, Veljko
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim was to estimate association of the oxidative stress with the occurrence of age-related macular degeneration (AMD).
The activities of erythrocyte antioxidant enzymes: superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) and additionally serum total antioxidant status (TAS) were used as indicators of the oxidative stress level.
57 AMD patients (32 early and 25 late AMD) and 50 healthy, age and gender matched controls were included.
GPx activity ( P < 0.001 ) and serum TAS ( P = 0.015 ) were significantly lower in AMD patients.
The difference was not significant for SOD or CAT activities.
Significant interaction between GPx and SOD was detected ( P = 0.003 ).
At high levels of SOD activity (over 75th percentile), one standard deviation decrease in GPx increases the odds for AMD for six times (OR = 6.22; P < 0.001 ).
ROC analysis revealed that combined values of GPx activity and TAS are significant determinants of AMD status.
Accuracy, sensitivity, specificity, and positive and negative predictive values were 75%, 95%, 52%, 69%, and 90%, respectively.
The study showed that low GPx activity and TAS are associated with AMD.
SOD modulates the association of GPx and AMD.
The results suggest that erythrocyte antioxidant enzymes activity and serum TAS could be promising markers for the prediction of AMD.
American Psychological Association (APA)
Plestina-Borjan, Ivna& Katusic, Damir& Medvidovic-Grubisic, Maria& Supe-Domic, Daniela& Bucan, Kajo& Tandara, Leida…[et al.]. 2015. Association of Age-Related Macular Degeneration with Erythrocyte Antioxidant Enzymes Activity and Serum Total Antioxidant Status. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075780
Modern Language Association (MLA)
Plestina-Borjan, Ivna…[et al.]. Association of Age-Related Macular Degeneration with Erythrocyte Antioxidant Enzymes Activity and Serum Total Antioxidant Status. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075780
American Medical Association (AMA)
Plestina-Borjan, Ivna& Katusic, Damir& Medvidovic-Grubisic, Maria& Supe-Domic, Daniela& Bucan, Kajo& Tandara, Leida…[et al.]. Association of Age-Related Macular Degeneration with Erythrocyte Antioxidant Enzymes Activity and Serum Total Antioxidant Status. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075780
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075780