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Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice
Joint Authors
Ruiz, Lina M.
Salazar, Celia
Jensen, Erik
Ruiz, Paula A.
Tiznado, William
Quintanilla, Rodrigo A.
Barreto, Marlen
Elorza, Alvaro A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Quercetin, a dietary flavonoid used as a food supplement, showed powerful antioxidant effects in different cellular models.
However, recent in vitro and in vivo studies in mammals have suggested a prooxidant effect of quercetin and described an interaction with mitochondria causing an increase in O2∙- production, a decrease in ATP levels, and impairment of respiratory chain in liver tissue.
Therefore, because of its dual actions, we studied the effect of quercetin in vivo to analyze heart mitochondrial function and erythropoiesis.
Mice were injected with 50 mg/kg of quercetin for 15 days.
Treatment with quercetin decreased body weight, serum insulin, and ceruloplasmin levels as compared with untreated mice.
Along with an impaired antioxidant capacity in plasma, quercetin-treated mice showed a significant delay on erythropoiesis progression.
Heart mitochondrial function was also impaired displaying more protein oxidation and less activity for IV, respectively, than no-treated mice.
In addition, a significant reduction in the protein expression levels of Mitofusin 2 and Voltage-Dependent Anion Carrier was observed.
All these results suggest that quercetin affects erythropoiesis and mitochondrial function and then its potential use as a dietary supplement should be reexamined.
American Psychological Association (APA)
Ruiz, Lina M.& Salazar, Celia& Jensen, Erik& Ruiz, Paula A.& Tiznado, William& Quintanilla, Rodrigo A.…[et al.]. 2015. Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075789
Modern Language Association (MLA)
Ruiz, Lina M.…[et al.]. Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075789
American Medical Association (AMA)
Ruiz, Lina M.& Salazar, Celia& Jensen, Erik& Ruiz, Paula A.& Tiznado, William& Quintanilla, Rodrigo A.…[et al.]. Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075789