Insulin Therapy of Nondiabetic Septic Patients Is Predicted by para-TyrosinePhenylalanine Ratio and by Hydroxyl Radical-Derived Products of Phenylalanine
Joint Authors
Kun, Szilárd
Molnár, Gergő A.
Sélley, Eszter
Szélig, Lívia
Bogár, Lajos
Csontos, Csaba
Miseta, Attila
Wittmann, István
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Hydroxyl radical converts Phe to para-, meta-, and ortho-Tyr (p-Tyr, m-Tyr, o-Tyr), while Phe is converted enzymatically to p-Tyr in the kidney and could serve as substrate for gluconeogenesis.
Pathological isoforms m- and o-Tyr are supposed to be involved in development of hormone resistances.
Role of Phe and the three Tyr isoforms in influencing insulin need was examined in 25 nondiabetic septic patients.
Daily insulin dose (DID) and insulin-glucose product (IGP) were calculated.
Serum and urinary levels of Phe and Tyr isoforms were determined using a rpHPLC-method.
Urinary m-Tyr/p-Tyr ratio was higher in patients with DID and IGP over median compared to those below median (P=0.005 and P=0.01, resp.).
Urinary m-Tyr and m-Tyr/p-Tyr ratio showed positive correlation with DID (P=0.009 and P=0.023, resp.) and with IGP (P=0.004 and P=0.008, resp.).
Serum Phe was a negative predictor, while serum p-Tyr/Phe ratio was positive predictor of both DID and IGP.
Urinary m-Tyr and urinary m-Tyr/p-Tyr, o-Tyr/p-Tyr, and (m-Tyr+o-Tyr)/p-Tyr ratios were positive predictors of both DID and IGP.
Phe and Tyr isoforms have a predictive role in carbohydrate metabolism of nondiabetic septic patients.
Phe may serve as substrate for renal gluconeogenesis via enzymatically produced p-Tyr, while hydroxyl radical derived Phe products may interfere with insulin action.
American Psychological Association (APA)
Kun, Szilárd& Molnár, Gergő A.& Sélley, Eszter& Szélig, Lívia& Bogár, Lajos& Csontos, Csaba…[et al.]. 2015. Insulin Therapy of Nondiabetic Septic Patients Is Predicted by para-TyrosinePhenylalanine Ratio and by Hydroxyl Radical-Derived Products of Phenylalanine. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075791
Modern Language Association (MLA)
Kun, Szilárd…[et al.]. Insulin Therapy of Nondiabetic Septic Patients Is Predicted by para-TyrosinePhenylalanine Ratio and by Hydroxyl Radical-Derived Products of Phenylalanine. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1075791
American Medical Association (AMA)
Kun, Szilárd& Molnár, Gergő A.& Sélley, Eszter& Szélig, Lívia& Bogár, Lajos& Csontos, Csaba…[et al.]. Insulin Therapy of Nondiabetic Septic Patients Is Predicted by para-TyrosinePhenylalanine Ratio and by Hydroxyl Radical-Derived Products of Phenylalanine. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075791
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075791