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Interactions between CYP3A4 and Dietary Polyphenols
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-09
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The human cytochrome P450 enzymes (P450s) catalyze oxidative reactions of a broad spectrum of substrates and play a critical role in the metabolism of xenobiotics, such as drugs and dietary compounds.
CYP3A4 is known to be the main enzyme involved in the metabolism of drugs and most other xenobiotics.
Dietary compounds, of which polyphenolics are the most studied, have been shown to interact with CYP3A4 and alter its expression and activity.
Traditionally, the liver was considered the prime site of CYP3A-mediated first-pass metabolic extraction, but in vitro and in vivo studies now suggest that the small intestine can be of equal or even greater importance for the metabolism of polyphenolics and drugs.
Recent studies have pointed to the role of gut microbiota in the metabolic fate of polyphenolics in human, suggesting their involvement in the complex interactions between dietary polyphenols and CYP3A4.
Last but not least, all the above suggests that coadministration of drugs and foods that are rich in polyphenols is expected to stimulate undesirable clinical consequences.
This review focuses on interactions between dietary polyphenols and CYP3A4 as they relate to structural considerations, food-drug interactions, and potential negative consequences of interactions between CYP3A4 and polyphenols.
American Psychological Association (APA)
Basheer, Loai& Kerem, Zohar. 2015. Interactions between CYP3A4 and Dietary Polyphenols. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1075797
Modern Language Association (MLA)
Basheer, Loai& Kerem, Zohar. Interactions between CYP3A4 and Dietary Polyphenols. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1075797
American Medical Association (AMA)
Basheer, Loai& Kerem, Zohar. Interactions between CYP3A4 and Dietary Polyphenols. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1075797
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075797