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Role of Oxidative Stress in Thyroid Hormone-Induced Cardiomyocyte Hypertrophy and Associated Cardiac Dysfunction: An Undisclosed Story
Joint Authors
Janssen, Paul M. L.
Mohler, Peter J.
Elnakish, Mohammad T.
Ahmed, Amany A. E.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-04
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Cardiac hypertrophy is the most documented cardiomyopathy following hyperthyroidism in experimental animals.
Thyroid hormone-induced cardiac hypertrophy is described as a relative ventricular hypertrophy that encompasses the whole heart and is linked with contractile abnormalities in both right and left ventricles.
The increase in oxidative stress that takes place in experimental hyperthyroidism proposes that reactive oxygen species are key players in the cardiomyopathy frequently reported in this endocrine disorder.
The goal of this review is to shed light on the effects of thyroid hormones on the development of oxidative stress in the heart along with the subsequent cellular and molecular changes.
In particular, we will review the role of thyroid hormone-induced oxidative stress in the development of cardiomyocyte hypertrophy and associated cardiac dysfunction, as well as the potential effectiveness of antioxidant treatments in attenuating these hyperthyroidism-induced abnormalities in experimental animal models.
American Psychological Association (APA)
Elnakish, Mohammad T.& Ahmed, Amany A. E.& Mohler, Peter J.& Janssen, Paul M. L.. 2015. Role of Oxidative Stress in Thyroid Hormone-Induced Cardiomyocyte Hypertrophy and Associated Cardiac Dysfunction: An Undisclosed Story. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1075798
Modern Language Association (MLA)
Elnakish, Mohammad T.…[et al.]. Role of Oxidative Stress in Thyroid Hormone-Induced Cardiomyocyte Hypertrophy and Associated Cardiac Dysfunction: An Undisclosed Story. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1075798
American Medical Association (AMA)
Elnakish, Mohammad T.& Ahmed, Amany A. E.& Mohler, Peter J.& Janssen, Paul M. L.. Role of Oxidative Stress in Thyroid Hormone-Induced Cardiomyocyte Hypertrophy and Associated Cardiac Dysfunction: An Undisclosed Story. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1075798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075798