New Insights for Oxidative Stress and Diabetes Mellitus
Author
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-12
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The release of reactive oxygen species (ROS) and the generation of oxidative stress are considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is growing in prevalence and results in significant economic loss.
New therapeutic directions that address the detrimental effects of oxidative stress may be especially warranted to develop effective care for the millions of individuals that currently suffer from DM.
The mechanistic target of rapamycin (mTOR), silent mating type information regulation 2 homolog 1 (S.
cerevisiae) (SIRT1), and Wnt1 inducible signaling pathway protein 1 (WISP1) are especially justified to be considered treatment targets for DM since these pathways can address the complex relationship between stem cells, trophic factors, impaired glucose tolerance, programmed cell death pathways of apoptosis and autophagy, tissue remodeling, cellular energy homeostasis, and vascular biology that greatly impact the biology and disease progression of DM.
The translation and development of these pathways into viable therapies will require detailed understanding of their proliferative nature to maximize clinical efficacy and limit adverse effects that have the potential to lead to unintended consequences.
American Psychological Association (APA)
Maiese, Kenneth. 2015. New Insights for Oxidative Stress and Diabetes Mellitus. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1075801
Modern Language Association (MLA)
Maiese, Kenneth. New Insights for Oxidative Stress and Diabetes Mellitus. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1075801
American Medical Association (AMA)
Maiese, Kenneth. New Insights for Oxidative Stress and Diabetes Mellitus. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1075801
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075801