The Protective Effects of Salidroside from Exhaustive Exercise-Induced Heart Injury by Enhancing the PGC-1α–NRF1NRF2 Pathway and Mitochondrial Respiratory Function in Rats
Joint Authors
Ping, Zheng
Zhang, Long-fei
Cui, Yu-juan
Chang, Yu-mei
Jiang, Cai-wu
Meng, Zhen-zhi
Xu, Peng
Liu, Hai-yan
Wang, Dong-ying
Cao, Xuebin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To test the hypothesis that salidroside (SAL) can protect heart from exhaustive exercise-induced injury by enhancing mitochondrial respiratory function and mitochondrial biogenesis key signaling pathway PGC-1α–NRF1/NRF2 in rats.
Methods.
Male Sprague-Dawley rats were divided into 4 groups: sedentary (C), exhaustive exercise (EE), low-dose SAL (LS), and high-dose SAL (HS).
After one-time exhaustive swimming exercise, we measured the changes in cardiomyocyte ultrastructure and cardiac marker enzymes and mitochondrial electron transport system (ETS) complexes activities in situ.
We also measured mitochondrial biogenesis master regulator PGC-1α and its downstream transcription factors, NRF1 and NRF2, expression at gene and protein levels.
Results.
Compared to C group, the EE group showed marked myocardium ultrastructure injury and decrease of mitochondrial respiratory function P<0.05 and protein levels of PGC-1α, NRF1, and NRF2 P<0.05 but a significant increase of PGC-1α, NRF1, and NRF2 genes levels P<0.05; compared to EE group, SAL ameliorated myocardium injury, increased mitochondrial respiratory function P<0.05, and elevated both gene and protein levels of PGC-1α, NRF-1, and NRF-2.
Conclusion.
Salidroside can protect the heart from exhaustive exercise-induced injury.
It might act by improving myocardial mitochondrial respiratory function by stimulating the expression of PGC-1α–NRF1/NRF2 pathway.
American Psychological Association (APA)
Ping, Zheng& Zhang, Long-fei& Cui, Yu-juan& Chang, Yu-mei& Jiang, Cai-wu& Meng, Zhen-zhi…[et al.]. 2015. The Protective Effects of Salidroside from Exhaustive Exercise-Induced Heart Injury by Enhancing the PGC-1α–NRF1NRF2 Pathway and Mitochondrial Respiratory Function in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075803
Modern Language Association (MLA)
Ping, Zheng…[et al.]. The Protective Effects of Salidroside from Exhaustive Exercise-Induced Heart Injury by Enhancing the PGC-1α–NRF1NRF2 Pathway and Mitochondrial Respiratory Function in Rats. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1075803
American Medical Association (AMA)
Ping, Zheng& Zhang, Long-fei& Cui, Yu-juan& Chang, Yu-mei& Jiang, Cai-wu& Meng, Zhen-zhi…[et al.]. The Protective Effects of Salidroside from Exhaustive Exercise-Induced Heart Injury by Enhancing the PGC-1α–NRF1NRF2 Pathway and Mitochondrial Respiratory Function in Rats. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075803