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Protective Pleiotropic Effect of Flavonoids on NAD + Levels in Endothelial Cells Exposed to High Glucose
Joint Authors
Boesten, Daniëlle M. P. H. J.
von Ungern-Sternberg, Saskia N. I.
Bast, Aalt
den Hartog, Gertjan J. M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
NAD+ is important for oxidative metabolism by serving as an electron transporter.
Hyperglycemia decreases NAD+ levels by activation of the polyol pathway and by overactivation of poly(ADP-ribose)-polymerase (PARP).
We examined the protective role of three structurally related flavonoids (rutin, quercetin, and flavone) during high glucose conditions in an in vitro model using human umbilical vein endothelial cells (HUVECs).
Additionally we assessed the ability of these flavonoids to inhibit aldose reductase enzyme activity.
We have previously shown that flavonoids can inhibit PARP activation.
Extending these studies, we here provide evidence that flavonoids are also able to protect endothelial cells against a high glucose induced decrease in NAD+.
In addition, we established that flavonoids are able to inhibit aldose reductase, the key enzyme in the polyol pathway.
We conclude that this protective effect of flavonoids on NAD+ levels is a combination of the flavonoids ability to inhibit both PARP activation and aldose reductase enzyme activity.
This study shows that flavonoids, by a combination of effects, maintain the redox state of the cell during hyperglycemia.
This mode of action enables flavonoids to ameliorate diabetic complications.
American Psychological Association (APA)
Boesten, Daniëlle M. P. H. J.& von Ungern-Sternberg, Saskia N. I.& den Hartog, Gertjan J. M.& Bast, Aalt. 2015. Protective Pleiotropic Effect of Flavonoids on NAD + Levels in Endothelial Cells Exposed to High Glucose. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075804
Modern Language Association (MLA)
Boesten, Daniëlle M. P. H. J.…[et al.]. Protective Pleiotropic Effect of Flavonoids on NAD + Levels in Endothelial Cells Exposed to High Glucose. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1075804
American Medical Association (AMA)
Boesten, Daniëlle M. P. H. J.& von Ungern-Sternberg, Saskia N. I.& den Hartog, Gertjan J. M.& Bast, Aalt. Protective Pleiotropic Effect of Flavonoids on NAD + Levels in Endothelial Cells Exposed to High Glucose. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075804
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075804