Allopurinol Protects against IschemiaReperfusion-Induced Injury in Rat Urinary Bladders
Joint Authors
Shin, Ju-Hyun
Chun, Kwang Sik
Na, Yong-Gil
Song, Ki-Hak
Kim, Seung Il
Lim, Jae-Sung
Kim, Gun-Hwa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Bladder ischemia-reperfusion (I/R) injury results in the generation of reactive oxygen species (ROS) and markedly elevates the risk of lower urinary tract symptoms (LUTS).
Allopurinol is an inhibitor of xanthine oxidase (XO) and thus can serve as an antioxidant that reduces oxidative stress.
Here, a rat model was used to assess the ability of allopurinol treatment to ameliorate the deleterious effects of urinary bladder I/R injury.
I/R injury reduced the in vitro contractile responses of longitudinal bladder strips, elevated XO activity in the plasma and bladder tissue, increased the bladder levels of tumor necrosis factor-α (TNF-α), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase, reduced the bladder levels of extracellular regulated kinase (ERK), and decreased and increased the bladder levels of Bcl-2 and Bax, respectively.
I/R injury also elevated lipid peroxidation in the bladder.
Allopurinol treatment in the I/R injury was generated significantly ameliorating all I/R-induced changes.
Moreover, an in situ fluorohistological approach also showed that allopurinol reduces the generation of intracellular superoxides enlarged by I/R injury.
Together, the beneficial effects of allopurinol reducing ROS production may be mediated by normalizing the activity of the ERK, JNK, and Bax/Bcl-2 pathways and by controlling TNF-α expression.
American Psychological Association (APA)
Shin, Ju-Hyun& Chun, Kwang Sik& Na, Yong-Gil& Song, Ki-Hak& Kim, Seung Il& Lim, Jae-Sung…[et al.]. 2015. Allopurinol Protects against IschemiaReperfusion-Induced Injury in Rat Urinary Bladders. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075807
Modern Language Association (MLA)
Shin, Ju-Hyun…[et al.]. Allopurinol Protects against IschemiaReperfusion-Induced Injury in Rat Urinary Bladders. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075807
American Medical Association (AMA)
Shin, Ju-Hyun& Chun, Kwang Sik& Na, Yong-Gil& Song, Ki-Hak& Kim, Seung Il& Lim, Jae-Sung…[et al.]. Allopurinol Protects against IschemiaReperfusion-Induced Injury in Rat Urinary Bladders. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075807